2. Gene
  3. LRCH3 - leucine rich repeats and calponin homology domain containing 3 Gene

LRCH3 - leucine rich repeats and calponin homology domain containing 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含富亮氨酸的重复序列和 calponin 同源域 3

种属: Homo sapiens

基因 ID: 84859 | 基因类型: protein coding

关于 LRCH3

This gene has 19 transcripts (splice variants), 199 orthologues and 31 paralogues. Ubiquitous expression in ovary (RPKM 3.8), lymph node (RPKM 3.6) and 25 other tissues.

功能概要

参与败血症细胞骨架组织。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Involved in septin Cytoskeleton organization. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LRCH3 基因产物(7)

mRNA Protein Name
NM_001363887.1 NP_001350816.1 DISP complex protein LRCH3 isoform 1
NM_001365715.1 NP_001352644.1 DISP complex protein LRCH3 isoform 3
NM_001365716.1 NP_001352645.1 DISP complex protein LRCH3 isoform 4
NM_001365717.1 NP_001352646.1 DISP complex protein LRCH3 isoform 5
NM_001365718.1 NP_001352647.1 DISP complex protein LRCH3 isoform 6
NM_001365719.2 NP_001352648.1 DISP complex protein LRCH3 isoform 7
NM_032773.4 NP_116162.1 DISP complex protein LRCH3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24255178 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in septin cytoskeleton organization IMP
IMP: 通过突变表型推断
29467281 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRCH3 蛋白结构

LRR_1

LRR_1: Leucine Rich Repeat (130 - 150)

LRR_8

LRR_8: Leucine rich repeat (152 - 208)

CH

CH: Calponin homology (CH) domain (662 - 762)

  • 0
  • 200
  • 400
  • 600
  • 777 a.a.
蛋白主名 其他名称

DISP complex protein LRCH3

leucine-rich repeat and calponin homology domain-containing protein 3

LRCH3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LRCH3 Q96II8 DOCK8 Homo sapiens Q8NF50-2
Y2H Prey Pooling
25416956
Intra LRCH3 Q96II8 DOCK8 Homo sapiens Q8NF50-2
Validated Y2H
25416956
Intra LRCH3 Q96II8 DOCK8 Homo sapiens Q8NF50-2
Y2H Array
25416956
Intra LRCH3 Q96II8 MYO6 Homo sapiens Q9UM54-1
Y2H
29467281
Intra LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
33961781
Intra LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
24255178
Intra LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
29467281
Intra LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
IF
29467281
Intra LRCH3 Q96II8 MYO6 Homo sapiens Q9UM54
Anti Tag CoIP
29467281
Intra LRCH3 Q96II8 MYO6 Homo sapiens Q9UM54
BioID
29467281
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Hypertrophic, 2

Hypertrophic Cardiomyopathy 2

CMH2

Cardiomyopathy, Hypertrophic, 2

Cardiomyopathy Familial Hypertrophic 2

Cardiomyopathy, Familial Hypertrophic 2

Cardiomyopathy, Hypertrophic, Familial, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07779 LRCH3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LRCH3 RGD RGD:1306200
Mus musculus LRCH3 MGD MGI:1917394
Felis catus LRCH3 VGNC VGNC:63274
Bos taurus LRCH3 VGNC VGNC:30973
Macaca mulatta LRCH3 VGNC VGNC:74382
Canis familiaris LRCH3 VGNC VGNC:53078
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