RIOX2 - ribosomal oxygenase 2 Gene

中文名称：核糖体加氧酶 2

种属: Homo sapiens

同用名: ROX; MDIG; MINA; NO52; JMJD10; MINA53

基因 ID: 84864 | 基因类型: protein coding

关于 RIOX2

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:97,941,818-97,972,431 (from NCBI)

This gene has 9 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 23.6), skin (RPKM 10.0) and 24 other tissues.

功能概要

MINA 是一种 c-Myc (MYC；MIM 190080) 靶基因，可能在细胞增殖或细胞生长调节中发挥作用。 (Tsuneoka 等人，2002 [PubMed 12091391]；Zhang 等人，2005 [PubMed 15897898]) 。[OMIM 提供，2008 年 5 月]

MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

RIOX2 基因产物(4)

mRNA	Protein	Name
NM_001042533.3	NP_001035998.1	ribosomal oxygenase 2 isoform a
NM_001261829.2	NP_001248758.1	ribosomal oxygenase 2 isoform b
NM_032778.6	NP_116167.3	ribosomal oxygenase 2 isoform b
NM_153182.4	NP_694822.2	ribosomal oxygenase 2 isoform a

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables peptidyl-histidine dioxygenase activity	EXP EXP: 通过实验结果推断	23103944	GOA
enables peptidyl-histidine dioxygenase activity	IDA IDA: 通过直接分析推断	23103944	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RIOX2 蛋白结构

Cupin_4

0
100
200
300
400
465 a.a.

蛋白主名

其他名称

ribosomal oxygenase 2

60S ribosomal protein L27a histidine hydroxylase

RIOX2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RIOX2	Q8IUF8	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	RIOX2	Q8IUF8	tax	Human T-cell leukemia virus	P03410	Y2H Array	22458338
种属内	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Prey Pooling	32296183
种属内	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Validated Y2H	32296183
种属内	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Array	25416956
种属内	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Array	32296183
种属内	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Pooling	16189514
种属内	RIOX2	Q8IUF8	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338
种属内	RIOX2	Q8IUF8	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338

种属间: 跨种属相互作用 种属内: 同种属相互作用

RIOX2 抗体

目录号	产品名	应用	反应物种
HY-P83497	Mint3 Antibody (YA3242)	WB, ICC/IF	Human, Mouse

关联疾病

疾病名称

别名

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11991	RIOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RIOX2	VGNC	VGNC:45593
Rattus norvegicus	RIOX2	RGD	RGD:708521
Macaca mulatta	RIOX2	VGNC	VGNC:76777
Felis catus	RIOX2	VGNC	VGNC:64639
Bos taurus	RIOX2	VGNC	VGNC:33980
Mus musculus	RIOX2	MGD	MGI:1914264

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