RSPO3 - R-spondin 3 Gene

中文名称：R-spondin 3

种属: Homo sapiens

同用名: PWTSR; THSD2; CRISTIN1

关于 RSPO3

功能概要

该基因属于 R-spondin 家族。编码的蛋白质在 Wnt (无翼型 MMTV 整合位点家族) /β-连环蛋白和 Wnt/平面细胞极性 (PCP) 信号通路的调控中发挥作用，这些信号通路参与发育、细胞生长和疾病发病机制。全基因组关联研究表明该基因与骨矿物质密度和骨折风险相关。该基因可能参与肿瘤的发展。[RefSeq 提供，2013 年 7 月]

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]