1. Gene
  2. AIFM2 - apoptosis inducing factor mitochondria associated 2 Gene

AIFM2 - apoptosis inducing factor mitochondria associated 2 Gene

中文名称:细胞凋亡诱导因子线粒体相关 2

种属: Homo sapiens

同用名: AMID; FSP1; PRG3

基因 ID: 84883 | 基因类型: protein coding

关于 AIFM2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,112,271-70,132,825 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Broad expression in fat (RPKM 26.6), thyroid (RPKM 7.3) and 22 other tissues.

功能概要

该基因编码一种结合单链 DNA 的黄素蛋白氧化还原酶,被认为在细菌和病毒 DNA 存在的情况下促进细胞凋亡。该基因的表达也被发现在结肠癌细胞中由肿瘤抑制蛋白 p53 诱导。[RefSeq 提供,2010 年 11 月]

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to Apoptosis in the presence of Bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon Cancer cells. [provided by RefSeq, Nov 2010]

AIFM2 基因产物(2)

mRNA Protein Name
NM_001198696.2 NP_001185625.1 ferroptosis suppressor protein 1
NM_032797.6 NP_116186.1 ferroptosis suppressor protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15958387 GOA
enables electron-transferring-flavoprotein dehydrogenase activity IDA
IDA: 通过直接分析推断
15958387 GOA
enables flavin adenine dinucleotide binding IDA
IDA: 通过直接分析推断
15958387 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: 通过直接分析推断
31634899 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: 通过直接分析推断
11980907 GOA
involved in cellular detoxification IDA
IDA: 通过直接分析推断
35922516 GOA
involved in negative regulation of ferroptosis IDA
IDA: 通过直接分析推断
35922516 GOA
involved in negative regulation of ferroptosis IMP
IMP: 通过突变表型推断
31634899 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
11980907 GOA
involved in ubiquinone metabolic process IDA
IDA: 通过直接分析推断
31634899 GOA
involved in vitamin K metabolic process IDA
IDA: 通过直接分析推断
35922516 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12135761 GOA
located in cytosol IDA
IDA: 通过直接分析推断
11980907 GOA
located in lipid droplet IDA
IDA: 通过直接分析推断
14741744 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
11980907 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
11980907 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
31634900 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AIFM2 蛋白结构

Pyr_redox_2

Pyr_redox_2: Pyridine nucleotide-disulphide oxidoreductase (13 - 289)

Pyr_redox

Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (145 - 213)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

ferroptosis suppressor protein 1

apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death

AIFM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AIFM2 Q9BRQ8 TRIM69 Homo sapiens Q86WT6-2 32296183
种属内
AIFM2 Q9BRQ8 TRIM69 Homo sapiens Q86WT6-2 32296183
种属内
AIFM2 Q9BRQ8 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
AIFM2 Q9BRQ8 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
AIFM2 Q9BRQ8 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
AIFM2 Q9BRQ8 CNPY4 Homo sapiens Q8N129 32296183
种属内
AIFM2 Q9BRQ8 CNPY4 Homo sapiens Q8N129 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

AIFM2 抗体

目录号 产品名 应用 反应物种
HY-P80679 AMID/FSP1 Antibody WB, IHC-F, IHC-P, ICC/IF, ELISA Human, Mouse, Monkey

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AIFM2 VGNC VGNC:37738
Rattus norvegicus AIFM2 RGD RGD:1304964
Macaca mulatta AIFM2 VGNC VGNC:69666
Mus musculus AIFM2 MGD MGI:1918611
Bos taurus AIFM2 VGNC VGNC:25762
Felis catus AIFM2 VGNC VGNC:59700
Others AIFM2 NCBI