2. Gene
  3. ATG4C - autophagy related 4C cysteine peptidase Gene

ATG4C - autophagy related 4C cysteine peptidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：自噬相关的 4C 半胱氨酸肽酶

种属: Homo sapiens

同用名: APG4C; AUTL1; AUTL3; APG4-C; HsAPG4C

基因 ID: 84938 | 基因类型: protein coding

关于 ATG4C

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,784,132-62,865,516 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 4.0), placenta (RPKM 3.4) and 25 other tissues.

功能概要

自噬是内源性蛋白质和受损细胞器在细胞内被破坏的过程。据推测，自噬对于分化、变态、非凋亡性细胞死亡和衰老过程中的细胞稳态和细胞重塑至关重要。在一些恶性肿瘤中已经描述了自噬水平降低，并且已经提出自噬在控制与癌症相关的不受调节的细胞生长中的作用。该基因编码自噬蛋白家族的一个成员。编码的蛋白质也被指定为半胱氨酸蛋白酶 C-54 家族的成员。已经表征了编码相同蛋白质的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]

ATG4C 基因产物(2)

mRNA Protein Name
NM_032852.4 NP_116241.2 cysteine protease ATG4C
NM_178221.3 NP_835739.1 cysteine protease ATG4C
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
21177865 GOA
enables cysteine-type peptidase activity IDA
IDA: 通过直接分析推断
21177865 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
21177865 GOA
involved in autophagy IDA
IDA: 通过直接分析推断
30661429 GOA
involved in protein delipidation IDA
IDA: 通过直接分析推断
29458288 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
21177865 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATG4C 蛋白结构

Peptidase_C54

Peptidase_C54: Peptidase family C54 (75 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

cysteine protease ATG4C

APG4 autophagy 4 homolog C

重组 ATG4C 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7619 ATG4C Protein, Human (His) Q96DT6 (M1-L458) ≥95%

关联疾病

疾病名称 别名
Exhibitionism
Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder

Rem Sleep Behaviour Disorder

Rapid Eye Movement Sleep Behaviour Disorder

Rem - [Rapid Eye Movement] Behaviour Disorder
Dependent Personality Disorder
Atypical Autism

Pdd
Paraphilia Disorder

Paraphilia

Paraphilias
Ceroid Lipofuscinosis, Neuronal, 1

Neuronal Ceroid Lipofuscinosis 1

CLN1

Infantile Neuronal Ceroid Lipofuscinosis

Cln1 Disease

Santavuori-Haltia Disease

Ceroid Lipofuscinosis, Neuronal, 1, Variable Age At Onset

Neuronal Ceroid Lipofuscinosis 1 Variable Age Of Onset

Ceroid Lipofuscinosis Neuronal 1

Cln1 Variable Age At Onset

Infantile Batten Disease

Neuronal Ceroid Lipofuscinosis, Infantile

Hagberg-Santavuori Disease

Incl

Juvenile Neuronal Ceroid Lipofuscinosis With Granular Osmiophilic Deposits

Neuronal Ceroid Lipofuscinosis With Variable Age At Onset

Santavuori Disease

Lipofuscinosis, Ceroid, Neuronal, Type 1

Ceroid Lipofuscinosis, Neuronal 1, Infantile
Vascular Parkinsonism
Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder
Echolalia
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Movement Disease

Movement Disorders

Movement Disorder
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01150 ATG4C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ATG4C VGNC VGNC:60004
Canis familiaris ATG4C VGNC VGNC:38224
Rattus norvegicus ATG4C RGD RGD:1598323
Mus musculus ATG4C MGD MGI:2651854
Macaca mulatta ATG4C VGNC VGNC:70079
Bos taurus ATG4C VGNC VGNC:26259
Others ATG4C NCBI
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