RELT - RELT TNF receptor Gene

中文名称：RELT 肿瘤坏死因子受体

种属: Homo sapiens

同用名: AI3C; TRLT; TNFRSF19L

关于 RELT

功能概要

由该基因编码的蛋白质是 TNF 受体超家族的成员。这种受体在血液组织中特别丰富。它已被证明可以激活 NF-kappaB 通路并选择性地结合 TNF 受体相关因子 1 (TRAF1) 。该受体能够在 CD3 信号传导存在的情况下刺激 T 细胞增殖，这表明其在免疫反应中的调节作用。已经报道了编码相同蛋白质的该基因的两个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]