ATG4D - autophagy related 4D cysteine peptidase Gene

中文名称：自噬相关的 4D 半胱氨酸肽酶

种属: Homo sapiens

同用名: APG4D; AUTL4; APG4-D; HsAPG4D

关于 ATG4D

功能概要

自噬是内源性蛋白质和受损细胞器在细胞内被破坏的过程。据推测，自噬对于分化、变态、非凋亡性细胞死亡和衰老过程中的细胞稳态和细胞重塑至关重要。在一些恶性肿瘤中已经描述了自噬水平降低，并且已经提出自噬在控制与癌症相关的不受调节的细胞生长中的作用。该基因属于 C54 内肽酶的自噬相关蛋白 4 (Atg4) 家族。该家族的成员编码的蛋白质在自噬体的生物发生中发挥作用，自噬体隔离细胞质和细胞器以被溶酶体降解。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]