1. Gene
  2. LIPF - lipase F, gastric type Gene

LIPF - lipase F, gastric type Gene

中文名称:脂肪酶 F,胃型

种属: Homo sapiens

同用名: GL; HGL; HLAL

基因 ID: 8513 | 基因类型: protein coding

关于 LIPF

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:88,664,442-88,678,814 (from NCBI)

This gene has 6 transcripts (splice variants), 154 orthologues and 5 paralogues. Restricted expression toward stomach (RPKM 9296.8).

功能概要

该基因编码胃脂肪酶,一种参与胃肠道中膳食甘油三酯消化的酶,负责人类发生的 30% 的脂肪消化过程。它由胃底粘膜中的胃主细胞分泌,在酸性 pH 条件下水解甘油三酯的酯键。该基因是脂肪酶保守基因家族的成员,在中性脂质代谢中发挥着独特的作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供,2010 年 11 月]

This gene encodes gastric Lipase, an Enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

LIPF 基因产物(4)

mRNA Protein Name
NM_001198828.2 NP_001185757.1 gastric triacylglycerol lipase isoform 3 precursor
NM_001198829.2 NP_001185758.1 gastric triacylglycerol lipase isoform 1 precursor
NM_001198830.2 NP_001185759.1 gastric triacylglycerol lipase isoform 4 precursor
NM_004190.4 NP_004181.1 gastric triacylglycerol lipase isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables triacylglycerol lipase activity IDA
IDA: 通过直接分析推断
2243091 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LIPF 蛋白结构

Abhydro_lipase

Abhydro_lipase: Partial alpha/beta-hydrolase lipase region (35 - 96)

Abhydrolase_1

Abhydrolase_1: alpha/beta hydrolase fold (111 - 381)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

gastric triacylglycerol lipase

gastric lipase

LIPF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LIPF P07098 LRSAM1 Homo sapiens Q6UWE0
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LIPF 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70262 Gastric lipase Protein, Human (HEK293, His, solution) AAI12273.1 (L20-K398) ≥95%
HY-P70262A Gastric lipase Protein, Human (HEK293, C-His) P07098 (L20-K398) ≥95%

关联疾病

疾病名称 别名
Lysosomal Acid Lipase Deficiency

Wolman Disease

Cholesteryl Ester Storage Disease

Lal Deficiency

Lipa Deficiency

Cholesterol Ester Storage Disease

CESD

Cholesterol Ester Hydrolase Deficiency

Acid Lipase Deficiency

Acid Esterase Deficiency

Familial Xanthomatosis

Wolman Xanthomatosis

Wolman'S Disease

Wolman'S Or Triglyceride Storage Type Iii Disease

Xanthomatosis, Familial

Liposomal Acid Lipase Deficiency, Wolman Type

Familial Visceral Xanthomatosis

Primary Familial Xanthomatosis

Primary Familial Xanthomatosis With Adrenal Calcification

Acid Lipase Disease

WOD

Acid Cholesteryl Ester Hydrolase Deficiency, Type 2

Cholesterol Ester Storage Disease
Lysosomal And Lipase Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus LIPF VGNC VGNC:107298
Mus musculus LIPF MGD MGI:1914967
Macaca mulatta LIPF VGNC VGNC:74422
Canis familiaris LIPF VGNC VGNC:42696
Rattus norvegicus LIPF RGD RGD:708441
Felis catus LIPF VGNC VGNC:68058
Others LIPF NCBI