2. Gene
  3. PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Gene

PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇 4 ,5-二磷酸 3-激酶，催化亚基 β

种属: Rattus norvegicus

基因 ID: 85243 | 基因类型: protein coding

关于 PIK3CB

Primary_assembly 8: 99,594,644-99,699,663 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in Kidney (RPKM 13.9), Lung (RPKM 81.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 1-磷脂酰肌醇-3-激酶活性。参与磷脂酰肌醇磷酸盐的生物合成过程。位于刷状缘膜。磷脂酰肌醇 3-激酶复合物的一部分。用于研究血栓形成。该基因的人类直系同源物与胶质母细胞瘤有关；前列腺癌；前列腺癌;和 2 型糖尿病。与人 PIK3CB（磷脂酰肌醇 4,5-二磷酸 3-激酶催化亚基 β）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

PIK3CB 基因产物(2)

mRNA Protein Name
NM_053481.2 NP_445933.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
NM_053481.2 NP_445933.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: 通过直接分析推断
11931646 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
12882977 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border membrane IDA
IDA: 通过直接分析推断
11931646 RGD
part of phosphatidylinositol 3-kinase complex IDA
IDA: 通过直接分析推断
12882977 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIK3CB 蛋白结构

PI3K_p85B

PI3K_p85B: smart00143 (40 - 117)

PI3K_rbd

PI3K_rbd: smart00144 (179 - 287)

C2_PI3K_class_I_beta_delta

C2_PI3K_class_I_beta_delta: cd08693 (323 - 500)

PI3Ka_I

PI3Ka_I: cd00872 (531 - 701)

PI3Kc_IA_beta

PI3Kc_IA_beta: cd05173 (705 - 1066)

  • 0
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  • 1000
  • 1070 a.a.
蛋白主名 其他名称

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

PI3-kinase p110 subunit beta

PI3-kinase subunit beta

PI3K

PI3K-beta

PI3Kbeta

catalytic phosphatidylinositol 3-kinase beta

p110beta

phosphatidylinositol 3-kinase, catalytic, beta polypeptide

phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta

phosphoinositide-3-kinase, catalytic, beta polypeptide

ptdIns-3-kinase p110

ptdIns-3-kinase subunit beta

ptdIns-3-kinase subunit p110-beta

serine/threonine protein kinase PIK3CB

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126077 MTI-31 Inhibitor 99.98% 否
HY-RS10526 PIK3CB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10527 Pik3cb Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10528 PIK3CB Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens PIK3CB NCBI NCBI:5291
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