2. Gene
  3. DGKZ - diacylglycerol kinase zeta Gene

DGKZ - diacylglycerol kinase zeta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：二酰甘油激酶 zeta

种属: Homo sapiens

同用名: DAGK5; DAGK6; DGK-ZETA; hDGKzeta

基因 ID: 8525 | 基因类型: protein coding

关于 DGKZ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,332,926-46,380,554 (from NCBI)

This gene has 24 transcripts (splice variants), 273 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 24.7), bone marrow (RPKM 15.6) and 24 other tissues.

功能概要

该基因编码的蛋白质属于真核二酰基甘油激酶家族。它可能通过调节细胞内信号级联和信号转导中的甘油二酯水平来减弱蛋白激酶 C 的活性。选择性剪接发生在该位点，并且已经鉴定出编码不同亚型的多个转录物变体。[RefSeq 提供，2010 年 11 月]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

DGKZ 基因产物(7)

mRNA Protein Name
NM_001105540.2 NP_001099010.1 diacylglycerol kinase zeta isoform 4
NM_001199266.2 NP_001186195.1 diacylglycerol kinase zeta isoform 5
NM_001199267.2 NP_001186196.1 diacylglycerol kinase zeta isoform 6
NM_001199268.2 NP_001186197.1 diacylglycerol kinase zeta isoform 7
NM_003646.4 NP_003637.2 diacylglycerol kinase zeta isoform 2
NM_201532.3 NP_963290.1 diacylglycerol kinase zeta isoform 1
NM_201533.3 NP_963291.2 diacylglycerol kinase zeta isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: 通过直接分析推断
15544348 GOA
enables kinase activity IDA
IDA: 通过直接分析推断
18004883 GOA
enables lipid kinase activity IDA
IDA: 通过直接分析推断
16286473 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15157668 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in diacylglycerol metabolic process IDA
IDA: 通过直接分析推断
15544348 GOA
involved in glycerolipid metabolic process IDA
IDA: 通过直接分析推断
22627129 GOA
involved in lipid phosphorylation IDA
IDA: 通过直接分析推断
15544348 GOA
involved in mitotic G1 DNA damage checkpoint signaling IGI
IGI: 通过遗传相互作用推断
16286473 GOA
involved in phosphatidic acid biosynthetic process IDA
IDA: 通过直接分析推断
15544348 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
22627129 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
15157668 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15157668 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGKZ 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (361 - 419)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (484 - 608)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (635 - 792)

Ank_5

Ank_5: Ankyrin repeats (many copies) (1031 - 1087)

  • 0
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  • 1000
  • 1117 a.a.
蛋白主名 其他名称

diacylglycerol kinase zeta

DAG kinase zeta

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153343A (S)-BAY 2965501 99.88% 否
HY-153793 DGKζ-IN-1 Inhibitor / 否
HY-RS03724 DGKZ Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DGKZ VGNC VGNC:39924
Macaca mulatta DGKZ VGNC VGNC:71789
Bos taurus DGKZ VGNC VGNC:54417
Rattus norvegicus DGKZ RGD RGD:70929
Mus musculus DGKZ MGD MGI:1278339
Felis catus DGKZ VGNC VGNC:61464
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