2. Gene
  3. MICALL1 - MICAL like 1 Gene

MICALL1 - MICAL like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MICAL 样 1

种属: Homo sapiens

同用名: MIRAB13; MICAL-L1

基因 ID: 85377 | 基因类型: protein coding

关于 MICALL1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,906,297-37,942,822 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性；磷脂酸结合活性；和小的 GTPase 结合活性。涉及多个过程，包括质膜管；蛋白质定位到核内体；和缓慢的内吞循环。位于晚期内体和循环内体膜。是膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MICALL1 基因产物(4)

mRNA Protein Name
NM_001410818.1 NP_001397747.1 MICAL-like protein 1 isoform 1
NM_001410819.1 NP_001397748.1 MICAL-like protein 1 isoform 2
NM_001410820.1 NP_001397749.1 MICAL-like protein 1 isoform 4
NM_033386.4 NP_203744.1 MICAL-like protein 1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23596323 GOA
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
23596323 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19864458 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
19864458 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytic recycling IMP
IMP: 通过突变表型推断
19864458 GOA
involved in endocytosis IMP
IMP: 通过突变表型推断
20801876 GOA
involved in plasma membrane tubulation IDA
IDA: 通过直接分析推断
23596323 GOA
involved in protein localization to endosome IMP
IMP: 通过突变表型推断
23596323 GOA
involved in protein targeting to membrane IMP
IMP: 通过突变表型推断
19864458 GOA
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
21795389 GOA
involved in slow endocytic recycling IMP
IMP: 通过突变表型推断
19864458 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of endosome membrane IDA
IDA: 通过直接分析推断
19864458 GOA
NOT located in early endosome IDA
IDA: 通过直接分析推断
21795389 GOA
located in late endosome IDA
IDA: 通过直接分析推断
21795389 GOA
NOT located in recycling endosome membrane IDA
IDA: 通过直接分析推断
21795389 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
19864458 GOA
NOT located in trans-Golgi network IDA
IDA: 通过直接分析推断
21795389 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MICALL1 蛋白结构

CH

CH: Calponin homology (CH) domain (7 - 107)

LIM

LIM: LIM domain (164 - 217)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (678 - 817)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 863 a.a.
蛋白主名 其他名称

MICAL-like protein 1

molecule interacting with Rab13

MICALL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MICALL1 Q8N3F8 EHD4 Homo sapiens Q9H223
Pull Down
19864458
Intra MICALL1 Q8N3F8 EHD4 Homo sapiens Q9H223
Anti Tag CoIP
33961781
Intra MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Y2H
19864458
Intra MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Anti Tag CoIP
33961781
Intra MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Y2H
27189942
Intra MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Pull Down
19864458
Intra MICALL1 Q8N3F8 EHD1 Homo sapiens Q9H4M9
Pull Down
19864458
Intra MICALL1 Q8N3F8 EHD1 Homo sapiens Q9H4M9
Anti Tag CoIP
33961781
Cross MICALL1 Q8N3F8 DPYSL2 Bos taurus O02675
Pull Down
20801876
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bardet-Biedl Syndrome 5

BBS5

Bardet-Biedl Syndrome, Type 5
Microvillus Inclusion Disease

Congenital Microvillous Atrophy

Intractable Diarrhea Of Infancy

Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities

Davidson Disease

Microvillous Inclusion Disease

Congenital Microvillus Atrophy

Mvid

Diarrhea 2 With Microvillus Atrophy

Mvd

Congenital Familial Protracted Diarrhea

Davidson'S Disease

Familial Enteropathy, Microvillus

Microvillus Atrophy, Congenital

Congenital Enteropathy

Familial Protracted Enteropathy

Microvillous Atrophy

Microvillus Atrophy With Diarrhea 2

Idi
Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1
Retinitis Pigmentosa 39

RP39

Retinitis Pigmentosa, Type 39
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08428 MICALL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MICALL1 VGNC VGNC:54528
Bos taurus MICALL1 VGNC VGNC:52803
Macaca mulatta MICALL1 VGNC VGNC:107801
Felis catus MICALL1 VGNC VGNC:97508
Mus musculus MICALL1 MGD MGI:105870
Rattus norvegicus MICALL1 RGD RGD:1305415
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