2. Gene
  3. NKD1 - NKD inhibitor of WNT signaling pathway 1 Gene

NKD1 - NKD inhibitor of WNT signaling pathway 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WNT 信号通路 1 的 NKD 抑制因子

种属: Homo sapiens

同用名: Naked1

基因 ID: 85407 | 基因类型: protein coding

关于 NKD1

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,548,396-50,649,249 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 1 paralogue. Broad expression in lung (RPKM 3.1), brain (RPKM 2.1) and 20 other tissues.

功能概要

在小鼠中，Nkd 是一种散乱的 (见 DVL1；MIM 601365) 结合蛋白，作为 Wnt 的负调节剂 (见 WNT1；MIM 164820) -β-连环蛋白 (见 MIM 116806) -Tcf (见 MIM 602272) 信号通路。[OMIM 提供，2003 年 6 月]

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

NKD1 基因产物(1)

mRNA Protein Name
NM_033119.5 NP_149110.1 protein naked cuticle homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15687260 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
27846906 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
15687260 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
15687260 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein phosphatase type 2A complex IDA
IDA: 通过直接分析推断
15687260 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein naked cuticle homolog 1

Dvl-binding protein

NKD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NKD1 Q969G9 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
种属内
NKD1 Q969G9 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
种属内
NKD1 Q969G9 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
种属内
NKD1 Q969G9 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
种属内
NKD1 Q969G9 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
NKD1 Q969G9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
种属内
NKD1 Q969G9 MDFI Homo sapiens Q99750
Validated Y2H
32296183
种属内
NKD1 Q969G9 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
NKD1 Q969G9 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
种属内
NKD1 Q969G9 DVL3 Homo sapiens Q92997
Y2H Array
32296183
种属内
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-1
Anti Bait CoIP
16567647
种属内
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-1
Anti Tag CoIP
16567647
种属内
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-2
Anti Tag CoIP
15687260
种属内
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-2
Anti Tag CoIP
16567647
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09317 NKD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NKD1 RGD RGD:1308491
Macaca mulatta NKD1 VGNC VGNC:75198
Canis familiaris NKD1 VGNC VGNC:43828
Bos taurus NKD1 VGNC VGNC:32093
Mus musculus NKD1 MGD MGI:2135954
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z