2. Gene
  3. Prkcq - protein kinase C, theta Gene

Prkcq - protein kinase C, theta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C, theta

种属: Rattus norvegicus

同用名: Pkcq

基因 ID: 85420 | 基因类型: protein coding

关于 Prkcq

Primary_assembly 17: 67,246,394-67,378,704 reverse strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 204 orthologues, 5 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 276.), Muscle (RPKM 269.6) and 7 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程，包括细胞成分生物发生的正向调节；蛋白质运输的积极调节；和对葡萄糖的反应。位于多个细胞成分中，包括神经肌肉接头；核;和肌膜。高胰岛素血症和前列腺癌的生物标志物。与人 PRKCQ（蛋白激酶 C theta）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cellular component biogenesis; positive regulation of protein transport; and response to glucose. Located in several cellular components, including neuromuscular junction; nucleus; and sarcolemma. Biomarker of hyperinsulinism and prostate adenocarcinoma. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcq 基因产物(2)

mRNA Protein Name
NM_001276721.1 NP_001263650.1 protein kinase C theta type
NM_001276721.1 NP_001263650.1 protein kinase C theta type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11698413 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12697665 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12697665 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
10944456 RGD
involved in positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
9353339 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
12697665 RGD
involved in positive regulation of protein secretion IDA
IDA: 通过直接分析推断
11095914 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
9353339 RGD
involved in regulation of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
9353339 RGD
involved in regulation of vasoconstriction IEP
IEP: 通过表达模式推断
16951045 RGD
involved in respiratory burst IEP
IEP: 通过表达模式推断
10218646 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
11914741 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15994856 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
7755564 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
11404218 RGD
involved in tissue regeneration IEP
IEP: 通过表达模式推断
12007632 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuromuscular junction IDA
IDA: 通过直接分析推断
7738116 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
7738116 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkcq 蛋白结构

C1_nPKC_theta-like_rpt1

C1_nPKC_theta-like_rpt1: cd20834 (152 - 212)

C1_nPKC_theta-like_rpt2

C1_nPKC_theta-like_rpt2: cd20837 (231 - 280)

STKc_nPKC_theta

STKc_nPKC_theta: cd05619 (373 - 703)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
蛋白主名 其他名称

protein kinase C theta type

nPKC-theta

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11137 PRKCQ Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11138 Prkcq Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11139 Prkcq Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkcq NCBI NCBI:5588
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