LGR5 - leucine rich repeat containing G protein-coupled receptor 5 Gene

中文名称：含富含亮氨酸重复序列的 G 蛋白偶联受体 5

种属: Homo sapiens

同用名: FEX; HG38; GPR49; GPR67; GRP49

基因 ID: 8549 | 基因类型: protein coding

关于 LGR5

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,439,129-71,586,310 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 22 paralogues. Biased expression in placenta (RPKM 11.9), small intestine (RPKM 3.2) and 8 other tissues.

功能概要

由该基因编码的蛋白质是富含亮氨酸的重复序列受体 (LGR) ，是 G 蛋白偶联的 7 跨膜受体 (GPCR) 超家族的成员。编码的蛋白质是 R-spondins 的受体，并参与典型的 Wnt 信号通路。这种蛋白质在胚胎后发育过程中在成体肠道干细胞的形成和维持中发挥作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LGR5 基因产物(3)

mRNA	Protein	Name
NM_001277226.2	NP_001264155.1	leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2 precursor
NM_001277227.2	NP_001264156.1	leucine-rich repeat-containing G-protein coupled receptor 5 isoform 3 precursor
NM_003667.4	NP_003658.1	leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables G protein-coupled receptor activity	IDA IDA: 通过直接分析推断	21693646	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21693646	GOA
enables transmembrane signaling receptor activity	IDA IDA: 通过直接分析推断	21693646	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	21693646	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	21693646	GOA
located in trans-Golgi network membrane	IDA IDA: 通过直接分析推断	23439653	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGR5 蛋白结构

LRRNT

LRR_8

LRR_5

LRR_1

LRR_8

7tm_1

0
200
400
600
800
907 a.a.

蛋白主名

其他名称

leucine-rich repeat-containing G-protein coupled receptor 5

G-protein coupled receptor 49

LGR5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LGR5	O75473	RSPO1	Homo sapiens	Q2MKA7	GMS	23809763
种属内	LGR5	O75473	RSPO1	Homo sapiens	Q2MKA7	Anti Tag CoIP	23809763
种属内	LGR5	O75473	RSPO1	Homo sapiens	Q2MKA7	X-Ray Diffraction	23809763

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LGR5 蛋白

目录号	产品名	蛋白编号	纯度
HY-P79308	Lgr5/GPR49 Protein, Human (CHO, hFc)	O75473 (G22-I560)	≥95%
HY-P700891	Lgr5/GPR49 Protein, Human (HEK293, hFc)	O75473-1 (G22-P543)	≥95%

LGR5 抗体

目录号	产品名	应用	反应物种
HY-P82097	LGR5 Antibody (YA1842)	WB, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Ankyloglossia With Or Without Tooth Anomalies

Ankyloglossia	ANKG
'Tongue-Tie'	Tongue-Tie
Tongue Tie	Aberrant Insertion Of Labial Frenulum
Aberrant Insertion Of Frenum Of Tongue	Short Frenulum Linguae
Short Frenulum Of Tongue

Mucositis

Inflammatory Disease Of Mucous Membrane

Gastrointestinal Mucositis

Mesenteric Vascular Occlusion

Colon Adenoma

Adenomatous Polyp Of Colon

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome	Rudiger Syndrome 1
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1	EEC1
Eec Syndrome 1	Eec Syndrome-1
Walker-Clodius Syndrome	Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome
Eec	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome	Ectrodactyly-Cleft Lip/Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate	Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome
Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome	Ectrodactyly-Cleft Lip-Palate Syndrome
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome

Intestinal Benign Neoplasm

Intestinal Neoplasms	Intestinal Tumors
Intestine Growth	Neoplasm Of Intestinal Tract

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Non-Syndromic X-Linked Intellectual Disability 107

Mrx107

X-Linked Mental Retardation 107

Chemical Colitis

Lymphangioma

Lymphatic Malformation	Lymphatic Malformations
Benign Lymphangioma	Congenital Lymphangioma
Lymphangiomas

Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome

ACOGS

Gastrointestinal System Benign Neoplasm

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Corneal Dystrophy, Posterior Polymorphous, 4

PPCD4

Posterior Polymorphous Corneal Dystrophy 4

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Immunodeficiency 58

IMD58	Severe Combined Immunodeficiency Due To Carmil2 Deficiency
Combined Immunodeficiency Due To Carmil2 Deficiency	Combined Immunodeficiency Due To Rltpr Deficiency

Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis

ECTD14	Ectodermal Dysplasia 14
Ectn14

Deafness, Autosomal Recessive 98

DFNB98	Autosomal Recessive Nonsyndromic Deafness 98
Autosomal Recessive Deafness 98	Deafness, Autosomal Recessive, 98
Deafness, Autosomal Recessive, Type 98

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99406	Petosemtamab	Degrader	96.95%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148918	E722-2648	Inhibitor	/	否
HY-RS07619	LGR5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99406A	Petosemtamab (FUT8-KO)		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LGR5	MGD	MGI:1341817
Macaca mulatta	LGR5	VGNC	VGNC:74181
Felis catus	LGR5	VGNC	VGNC:67431
Bos taurus	LGR5	VGNC	VGNC:30862
Rattus norvegicus	LGR5	RGD	RGD:1307733
Others	LGR5	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LGR5 - leucine rich repeat containing G protein-coupled receptor 5 Gene

关于 LGR5

功能概要

LGR5 基因产物(3)

LGR5 蛋白结构

LGR5 蛋白互作信息

重组 LGR5 蛋白

LGR5 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

LGR5 - leucine rich repeat containing G protein-coupled receptor 5 Gene

关于 LGR5

功能概要

LGR5 基因产物(3)

LGR5 蛋白结构

LGR5 蛋白互作信息

重组 LGR5 蛋白

LGR5 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z