2. Gene
  3. GALP - galanin like peptide Gene

GALP - galanin like peptide Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甘丙肽样肽

种属: Homo sapiens

基因 ID: 85569 | 基因类型: protein coding

关于 GALP

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:56,176,008-56,185,775 (from NCBI)

This gene has 3 transcripts (splice variants) and 52 orthologues. Low expression observed in reference dataset.

功能概要

该基因编码神经肽甘丙肽家族的成员。编码的蛋白质结合甘丙肽受体 1、2 和 3，对甘丙肽受体 3 具有最高的亲和力，并且涉及涉及中枢神经系统的生物过程，包括下丘脑对代谢和繁殖的调节。由该基因的剪接变体编码的肽，称为 alarin，具有血管活性，显示出对大肠杆菌的抗菌活性，并可作为神经母细胞肿瘤的标志物。[RefSeq 提供，2014 年 11 月]

This gene encodes a member of the Galanin family of neuropeptides. The encoded protein binds Galanin receptors 1, 2 and 3 with the highest affinity for Galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]

GALP 基因产物(2)

mRNA Protein Name
NM_001145546.2 NP_001139018.1 galanin-like peptide isoform 2 precursor
NM_033106.4 NP_149097.1 galanin-like peptide isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: 通过突变表型推断
23537644 GOA
involved in defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
23537644 GOA
involved in modulation of process of another organism IMP
IMP: 通过突变表型推断
23537644 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GALP 蛋白结构

Galanin

Galanin: Galanin (33 - 45)

  • 0
  • 100
  • 116 a.a.
蛋白主名 其他名称

galanin-like peptide

alarin

GALP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GALP Q9UBC7 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
GALP Q9UBC7 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
GALP Q9UBC7 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
GALP Q9UBC7 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属内
GALP Q9UBC7 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ganglioneuroblastoma
Ganglioneuroma
Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

Ibd25

Inflammatory Bowel Disease 25, Autosomal Recessive
Spherocytosis, Type 3

Hereditary Spherocytosis Type 3

SPH3

Hs3

Spherocytosis, Hereditary, 3

Hereditary Spherocytosis 3

Spherocytosis 3
Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p

CMD1P

Cardiomyopathy, Dilated 1p

Cardiomyopathy, Dilated, Type 1p
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P5894 human GALP (3-32) Antagonist / 否
HY-RS05263 GALP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GALP VGNC VGNC:41099
Mus musculus GALP MGD MGI:2663979
Rattus norvegicus GALP RGD RGD:620187
Macaca mulatta GALP VGNC VGNC:72775
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