2. Gene
  3. CDK10 - cyclin dependent kinase 10 Gene

CDK10 - cyclin dependent kinase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 10

种属: Homo sapiens

同用名: ALSAS; PISSLRE

基因 ID: 8558 | 基因类型: protein coding

关于 CDK10

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,686,689-89,696,354 (from NCBI)

This gene has 22 transcripts (splice variants), 200 orthologues, 26 paralogues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 16.8), thyroid (RPKM 15.2) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 Ser/Thr 蛋白激酶家族的 CDK 亚家族。 CDK 亚家族成员与 S. cerevisiae cdc28 和 S. pombe cdc2 的基因产物高度相似，并且已知对细胞周期进程至关重要。该激酶已被证明在细胞增殖中发挥作用，其功能仅限于细胞周期 G2-M 期。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 5 月]

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

CDK10 基因产物(4)

mRNA Protein Name
NM_001098533.3 NP_001092003.2 cyclin-dependent kinase 10 isoform c
NM_001160367.2 NP_001153839.1 cyclin-dependent kinase 10 isoform d
NM_052987.4 NP_443713.2 cyclin-dependent kinase 10 isoform b
NM_052988.5 NP_443714.3 cyclin-dependent kinase 10 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18242510 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
27104747 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cilium assembly IMP
IMP: 通过突变表型推断
27104747 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
27104747 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
27104747 GOA
involved in regulation of cell cycle G2/M phase transition IDA
IDA: 通过直接分析推断
7664269 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ciliary basal body IDA
IDA: 通过直接分析推断
27104747 GOA
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
24218572 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11006117 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK10 蛋白结构

Pkinase

Pkinase: Protein kinase domain (39 - 323)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 10

CDC2-related protein kinase

CDK10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDK10 Q15131 HSPA8 Homo sapiens P11142
Anti Tag CoIP
33961781
种属内
CDK10 Q15131 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
CDK10 Q15131 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
CDK10 Q15131 PIN1 Homo sapiens Q13526
Anti Bait CoIP
22158035
种属内
CDK10 Q15131 PIN1 Homo sapiens Q13526
Anti Tag CoIP
22158035
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Al Kaissi Syndrome

ALKAS

Growth Retardation, Spine Malformation, Dysmorphic Facies, And Developmental Delay
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly

Du Pan Syndrome

AMD2B

Dupans

Acromesomelic Dysplasia-2b

Fibular Aplasia-Complex Brachydactyly Syndrome
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107419 NU6140 Inhibitor 99.07% 否
HY-RS02351 CDK10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDK10 RGD RGD:1304851
Macaca mulatta CDK10 VGNC VGNC:99499
Canis familiaris CDK10 VGNC VGNC:39043
Bos taurus CDK10 VGNC VGNC:27116
Felis catus CDK10 VGNC VGNC:60693
Mus musculus CDK10 MGD MGI:2448549
Others CDK10 NCBI
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