2. Gene
  3. PDLIM4 - PDZ and LIM domain 4 Gene

PDLIM4 - PDZ and LIM domain 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PDZ 和 LIM 域 4

种属: Homo sapiens

同用名: RIL

基因 ID: 8572 | 基因类型: protein coding

关于 PDLIM4

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,257,696-132,273,454 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 8.6), prostate (RPKM 6.1) and 21 other tissues.

功能概要

该基因编码一种可能参与骨骼发育的蛋白质。该基因的突变与骨质疏松症的易感性有关。[RefSeq 提供，2009 年 11 月]

This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis. [provided by RefSeq, Nov 2009]

PDLIM4 基因产物(2)

mRNA Protein Name
NM_001131027.2 NP_001124499.1 PDZ and LIM domain protein 4 isoform 2
NM_003687.4 NP_003678.2 PDZ and LIM domain protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-actinin binding IPI
IPI: 通过物理相互作用推断
20120020 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10826496 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
25158098 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
19307596 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
21636573 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21636573 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
21636573 GOA
part of filamentous actin IDA
IDA: 通过直接分析推断
10826496 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
10826496 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10826496 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
19307596 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
21636573 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDLIM4 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (9 - 80)

LIM

LIM: LIM domain (255 - 305)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

PDZ and LIM domain protein 4

LIM domain protein

PDLIM4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDLIM4 P50479 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Bone Mineral Density Quantitative Trait Locus 15

Osteoporosis

BMND15

Osteoporosis, Susceptibility To

Metaphyseal Fracture

Metaphyseal Fracture, Susceptibility To

Compression Fracture

Compression Fracture, Susceptibility To

Metaphyseal Fractures

Fractures, Compression
Castration-Resistant Prostate Carcinoma

Prostatic Neoplasms, Castration-Resistant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10282 PDLIM4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PDLIM4 RGD RGD:3575
Bos taurus PDLIM4 VGNC VGNC:32710
Canis familiaris PDLIM4 VGNC VGNC:44386
Felis catus PDLIM4 VGNC VGNC:64091
Macaca mulatta PDLIM4 VGNC VGNC:75809
Mus musculus PDLIM4 MGD MGI:1353470
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