PLPP2 - phospholipid phosphatase 2 Gene

中文名称：磷脂磷酸酶 2

种属: Homo sapiens

同用名: LPP2; PAP-2c; PAP2-g; PPAP2C

关于 PLPP2

功能概要

该基因编码的蛋白质是磷脂酸磷酸酶 (PAP) 家族的成员。 PAP 将磷脂酸转化为甘油二酯，并在甘油脂的从头合成以及磷脂酶 D 介导的受体激活信号转导中发挥作用。该蛋白质类似于 2A 型磷脂酸磷酸酶 (PPAP2A) 和 2B 型磷脂酸磷酸酶 (PPAP2B) 。所有三种蛋白质均包含 6 个跨膜区和一个共有 N-糖基化位点。这种蛋白质已被证明具有膜相关的 PAP 活性。已经报道了编码不同亚型的三种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is similar to phosphatidic Acid Phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]