JRK - Jrk helix-turn-helix protein Gene

中文名称：Jrk 螺旋-转角-螺旋蛋白

种属: Homo sapiens

同用名: JH8; jerky

基因 ID: 8629 | 基因类型: protein coding

关于 JRK

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,643,682-142,669,967 (from NCBI)

This gene has 11 transcripts (splice variants), 118 orthologues, 11 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 2.4), ovary (RPKM 2.3) and 24 other tissues.

功能概要

该基因编码一种类似于 DNA 结合蛋白的保守蛋白，例如主要着丝粒自身抗原 B (CENPB) 。小鼠相关基因的失活导致癫痫发作。儿童失神癫痫 (CAE) 已被定位到与该基因相同的染色体位置 (8q24.3) 。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

JRK 基因产物(3)

mRNA	Protein	Name
NM_001077527.3	NP_001070995.2	jerky protein homolog isoform b
NM_001279352.2	NP_001266281.1	jerky protein homolog isoform b
NM_003724.4	NP_003715.3	jerky protein homolog isoform a

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21399610	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	21399610	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

jerky protein homolog

Jrk homolog

JRK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	JRK	O75564	CTNNB1	Homo sapiens	P35222	Pull Down	21399610
种属间	JRK	O75564	Lef1	Mus musculus	P27782	Pull Down	21399610

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy	Janz Syndrome
Jme	Myoclonic Epilepsy, Juvenile, Susceptibility To, 1
EJM	Myoclonic Epilepsy, Juvenile
Petit Mal, Impulsive	Myoclonic Epilepsy, Juvenile 1
Myoclonic Epilepsy, Juvenile, 1	Adolescent Myoclonic Epilepsy
Juvenile Myoclonus Epilepsy	Juvenile Myoclonic Epilepsy 1
EJM1	Petit Mal Impulsive
Susceptibility To Juvenile Myoclonic Epilepsy 1	Myoclonic Epilepsy Juvenile
Epilepsy, Myoclonic, Juvenile	Myoclonic Epilepsy Of Janz
Jme - [Juvenile Myoclonic Epilepsy]

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Argyll Robertson Pupil

Atypical Argyll-Robertson Pupil	Argyll Robertson Phenomenon Or Pupil, Nonsyphilitic
Argyll Robertson Pupil, Atypical

Abnormal Pupillary Function

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07051	JRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	JRK	VGNC	VGNC:81663
Mus musculus	JRK	MGD	MGI:106214
Rattus norvegicus	JRK	RGD	RGD:1306316
Macaca mulatta	JRK	VGNC	VGNC:73957
Bos taurus	JRK	VGNC	VGNC:106789

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

JRK - Jrk helix-turn-helix protein Gene

关于 JRK

功能概要

JRK 基因产物(3)

JRK 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

JRK - Jrk helix-turn-helix protein Gene

关于 JRK

功能概要

JRK 基因产物(3)

JRK 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z