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  2. RTCA - RNA 3'-terminal phosphate cyclase Gene

RTCA - RNA 3'-terminal phosphate cyclase Gene

中文名称:RNA 3'-末端磷酸环化酶

种属: Homo sapiens

同用名: RPC; RTC1; RTCD1

基因 ID: 8634 | 基因类型: protein coding

关于 RTCA

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,266,216-100,292,769 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 10.7), kidney (RPKM 10.6) and 25 other tissues.

功能概要

该基因编码 RNA 3'-磷酸环化酶家族的一个成员。编码的蛋白质通过催化依赖 ATP 的 RNA 底物的 3'-磷酸转化为 2',3'-环状磷酸二酯,在 RNA 代谢中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 2 月]

This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

RTCA 基因产物(2)

mRNA Protein Name
NM_001130841.2 NP_001124313.1 RNA 3'-terminal phosphate cyclase isoform a
NM_003729.4 NP_003720.1 RNA 3'-terminal phosphate cyclase isoform b
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA-3'-phosphate cyclase activity IDA
IDA: 通过直接分析推断
9184239 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleoplasm IDA
IDA: 通过直接分析推断
9184239 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RTCA 蛋白结构

RTC

RTC: RNA 3'-terminal phosphate cyclase (8 - 339)

RTC_insert

RTC_insert: RNA 3'-terminal phosphate cyclase (RTC), insert domain (184 - 288)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
蛋白主名 其他名称

RNA 3'-terminal phosphate cyclase

RNA terminal phosphate cyclase domain 1

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C

FANCC

Facc

Fac

Fa3

Fanconi Pancytopenia Type 3

Fanconi Pancytopenia, Type 3

Faces Syndrome

Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

Friedman-Goodman Syndrome

Abnormality Of The Face

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus RTCA VGNC VGNC:64804
Bos taurus RTCA VGNC VGNC:34193
Macaca mulatta RTCA VGNC VGNC:77043
Canis familiaris RTCA VGNC VGNC:54065
Mus musculus RTCA MGD MGI:1913618
Rattus norvegicus RTCA RGD RGD:1303111