1. Gene
  2. OASL - 2'-5'-oligoadenylate synthetase like Gene

OASL - 2'-5'-oligoadenylate synthetase like Gene

中文名称:2'-5'-寡聚腺苷酸合成酶

种属: Homo sapiens

同用名: OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL

基因 ID: 8638 | 基因类型: protein coding

关于 OASL

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,017,761-121,039,246 (from NCBI)

This gene has 11 transcripts (splice variants), 123 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues.

功能概要

启用 DNA 结合活性和双链 RNA 结合活性。参与多个过程,包括 interleukin-27 介导的信号通路;病毒基因组复制的负调控; RIG-I 信号通路的正调控。位于胞质溶胶中;核仁;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OASL 基因产物(5)

mRNA Protein Name
NM_001261825.2 NP_001248754.1 2'-5'-oligoadenylate synthase-like protein isoform c
NM_001395418.1 NP_001382347.1 2'-5'-oligoadenylate synthase-like protein isoform b
NM_001395419.1 NP_001382348.1 2'-5'-oligoadenylate synthase-like protein isoform d
NM_003733.4 NP_003724.1 2'-5'-oligoadenylate synthase-like protein isoform a
NM_198213.3 NP_937856.1 2'-5'-oligoadenylate synthase-like protein isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables 2'-5'-oligoadenylate synthetase activity IDA
IDA: 通过直接分析推断
9826176 GOA
enables DNA binding IDA
IDA: 通过直接分析推断
9826176 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
9826176 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30833792 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IDA
IDA: 通过直接分析推断
21478870 GOA
involved in interleukin-27-mediated signaling pathway IEP
IEP: 通过表达模式推断
32270034 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
18931074 GOA
involved in positive regulation of RIG-I signaling pathway IDA
IDA: 通过直接分析推断
25925578 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
18931074 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9826176 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
9826176 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OASL 蛋白结构

OAS1_C

OAS1_C: 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus (167 - 350)

ubiquitin

ubiquitin: Ubiquitin family (439 - 506)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
蛋白主名 其他名称

2'-5'-oligoadenylate synthase-like protein

2'-5'-OAS-RP

OASL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OASL Q15646 LARP7 Homo sapiens Q4G0J3 33961781
种属内
OASL Q15646 LARP7 Homo sapiens Q4G0J3 30833792
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies

West Nile Fever
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus OASL VGNC VGNC:32392
Canis familiaris OASL VGNC VGNC:44089
Mus musculus OASL MGD MGI:2180849
Rattus norvegicus OASL RGD RGD:1308586
Macaca mulatta OASL VGNC VGNC:75572
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