2. Gene
  3. TNFSF12 - TNF superfamily member 12 Gene

TNFSF12 - TNF superfamily member 12 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 超家族成员 12

种属: Homo sapiens

同用名: APO3L; DR3LG; TWEAK; TNLG4A

基因 ID: 8742 | 基因类型: protein coding

关于 TNFSF12

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,549,058-7,557,881 (from NCBI)

This gene has 20 transcripts (splice variants), 85 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 27.5), lung (RPKM 20.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种属于肿瘤坏死因子 (TNF) 配体家族的细胞因子。该蛋白是 FN14/TWEAKR 受体的配体。这种细胞因子与 TNF 具有重叠的信号功能，但显示出更广泛的组织分布。这种以膜结合和分泌形式存在的细胞因子可以以细胞类型特异性方式通过多种细胞死亡途径诱导细胞凋亡。还发现这种细胞因子促进内皮细胞的增殖和迁移，因此充当血管生成的调节剂。可变剪接导致多个转录本变体。一些转录本跳过该基因的最后一个外显子并继续进入相邻 TNFSF13 基因的第二个外显子；此类通读转录本包含在 GeneID 407977，TNFSF12-TNFSF13 中。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce Apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF12 基因产物(1)

mRNA Protein Name
NM_003809.3 NP_003800.1 tumor necrosis factor ligand superfamily member 12 proprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14961121 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
21525013 GOA
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
17389268 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
14961121 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFSF12 蛋白结构

TNF

TNF: TNF(Tumour Necrosis Factor) family (132 - 248)

  • 0
  • 100
  • 200
  • 249 a.a.
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 12

APO3 ligand

重组 TNFSF12 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7309 TWEAK/TNFSF12 Protein, Human (CHO) O43508-1/Q4ACW9 (R99-H249) ≥95%
HY-P77263 TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, Fc) F7HGN4 (S94-H249) ≥95%
HY-P700156AF Animal-Free TWEAK/TNFSF12 Protein, Human (His) O43508 (K97-H249) ≥95%
HY-P701045 TWEAK/TNFSF12 Protein, Human (HEK293, hFc) O43508-1 (S43-H249) ≥95%

关联疾病

疾病名称 别名
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome
Amnestic Disorder

Amnesia

Amnestic Syndrome

Korsakoff'S Psychosis Or Syndrome

Amnesic Syndrome

Amnestic Disorder In Conditions Classified Elsewhere

Korsakoff Psychosis Or Syndrome, Nonalcoholic

Nonalcoholic Organic Amnesic Syndrome

Organic Amnesic Syndrome
Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome
Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14822 TNFSF12 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TNFSF12 VGNC VGNC:55878
Rattus norvegicus TNFSF12 RGD RGD:1359620
Mus musculus TNFSF12 MGD MGI:1196259
Macaca fascicularis TNFSF12 NCBI NCBI:102128998
Others TNFSF12 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z