2. Gene
  3. CD164 - CD164 molecule Gene

CD164 - CD164 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD164 分子

种属: Homo sapiens

同用名: DFNA66; MGC-24; MUC-24; MGC-24v; endolyn

基因 ID: 8763 | 基因类型: protein coding

关于 CD164

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,366,514-109,382,467 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 246.6), fat (RPKM 191.2) and 25 other tissues.

功能概要

该基因编码跨膜唾液酸粘蛋白和细胞粘附分子，可调节造血祖细胞的增殖、粘附和迁移。编码的蛋白质还与 CXC 趋化因子受体 4 相互作用，并可能调节肌肉发育。在患有 Sezary 综合征 (一种血癌) 的人类患者中观察到该基因的表达升高，并且该基因的突变可能与听力受损有关。[RefSeq 提供，2016 年 10 月]

This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C Chemokine Receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood Cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]

CD164 基因产物(6)

mRNA Protein Name
NM_001142401.3 NP_001135873.1 sialomucin core protein 24 isoform 2 precursor
NM_001142402.3 NP_001135874.1 sialomucin core protein 24 isoform 3 precursor
NM_001142403.3 NP_001135875.1 sialomucin core protein 24 isoform 4 precursor
NM_001142404.3 NP_001135876.1 sialomucin core protein 24 isoform 5 precursor
NM_001346500.2 NP_001333429.1 sialomucin core protein 24 isoform 6
NM_006016.6 NP_006007.2 sialomucin core protein 24 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17077324 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell adhesion IDA
IDA: 通过直接分析推断
10491205 GOA
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: 通过直接分析推断
10491205 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
11027692 GOA
located in lysosome IDA
IDA: 通过直接分析推断
11027692 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10491205 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD164 蛋白结构

MGC-24

MGC-24: Multi-glycosylated core protein 24 (MGC-24), sialomucin (5 - 189)

  • 0
  • 100
  • 197 a.a.
蛋白主名 其他名称

sialomucin core protein 24

CD164 antigen, sialomucin

CD164 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD164 Q04900 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
CD164 Q04900 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
CD164 Q04900 CXCR4 Homo sapiens P61073
Anti Bait CoIP
24094005
种属内
CD164 Q04900 HOXA1 Homo sapiens P49639
Y2H Array
32296183
种属内
CD164 Q04900 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
种属内
CD164 Q04900 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD164 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75617 CD164 Protein, Human (HEK293, His) Q04900 (D24-D162) ≥95%

关联疾病

疾病名称 别名
Deafness, Autosomal Dominant 66

DFNA66

Autosomal Dominant Nonsyndromic Deafness 66

Autosomal Dominant Deafness 66

Deafness, Autosomal Dominant, 66
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Isolated Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02194 CD164 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02195 CD164L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CD164 VGNC VGNC:70753
Felis catus CD164 VGNC VGNC:102397
Rattus norvegicus CD164 RGD RGD:70942
Mus musculus CD164 MGD MGI:1859568
Bos taurus CD164 VGNC VGNC:27004
Canis familiaris CD164 VGNC VGNC:38932
Macaca fascicularis CD164 NCBI NCBI:102136974
Others CD164 NCBI
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