2. Gene
  3. IL18R1 - interleukin 18 receptor 1 Gene

IL18R1 - interleukin 18 receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白介素 18 受体 1

种属: Homo sapiens

同用名: CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha

基因 ID: 8809 | 基因类型: protein coding

关于 IL18R1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,355,796-102,398,776 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 10 paralogues. Broad expression in appendix (RPKM 4.6), gall bladder (RPKM 3.7) and 21 other tissues.

功能概要

该基因编码的蛋白质是属于白介素 1 受体家族的细胞因子受体。该受体特异性结合白细胞介素 18 (IL18) ，对于 IL18 介导的信号转导至关重要。据报道，IFN-α 和 IL12 可诱导该受体在 NK 和 T 细胞中的表达。该基因连同白细胞介素 1 受体家族的其他四个成员，包括 IL1R2、IL1R1、ILRL2 (IL-1Rrp2) 和 IL1RL1 (T1/ST2) ，在染色体 2q 上形成一个基因簇。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four Other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

IL18R1 基因产物(9)

mRNA Protein Name
NM_001282399.2 NP_001269328.1 interleukin-18 receptor 1 isoform 2
NM_001371418.1 NP_001358347.1 interleukin-18 receptor 1 isoform 3 precursor
NM_001371419.1 NP_001358348.1 interleukin-18 receptor 1 isoform 4 precursor
NM_001371420.1 NP_001358349.1 interleukin-18 receptor 1 isoform 5 precursor
NM_001371421.1 NP_001358350.1 interleukin-18 receptor 1 isoform 6
NM_001371422.1 NP_001358351.1 interleukin-18 receptor 1 isoform 7
NM_001371423.1 NP_001358352.1 interleukin-18 receptor 1 isoform 8
NM_001371424.1 NP_001358353.1 interleukin-18 receptor 1 isoform 8
NM_003855.5 NP_003846.1 interleukin-18 receptor 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-18 binding IDA
IDA: 通过直接分析推断
14528293 GOA
enables interleukin-18 receptor activity IDA
IDA: 通过直接分析推断
25500532 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25261253 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-18-mediated signaling pathway IDA
IDA: 通过直接分析推断
25500532 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
25500532 GOA
involved in positive regulation of T-helper 1 cell cytokine production IDA
IDA: 通过直接分析推断
10653850 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
10653850 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of interleukin-18 receptor complex IDA
IDA: 通过直接分析推断
25500532 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL18R1 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (129 - 206)

Ig_3

Ig_3: Immunoglobulin domain (215 - 300)

TIR

TIR: TIR domain (377 - 518)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 541 a.a.
蛋白主名 其他名称

interleukin-18 receptor 1

CD218 antigen-like family member A

IL18R1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL18R1 Q13478 IL18 Homo sapiens Q14116
GMS
25261253
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL18R1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75842 IL-18R alpha Protein, Human (HEK293, Fc) Q13478 (A19-R329) ≥95%
HY-P75843 IL-18R alpha Protein, Human (HEK293, His) Q13478 (A19-R329) ≥95%
HY-P77710 IL-18R alpha Protein, Human (HEK293, His-Avi) Q13478 (A19-R329) ≥95%
HY-P77711 IL-18R alpha Protein, Human (Biotinylated, HEK293, His-Avi) Q13478 (A19-R329) ≥95%

关联疾病

疾病名称 别名
Laron Syndrome

Growth Hormone Insensitivity Syndrome

Growth Hormone Receptor Deficiency

Laron Dwarfism

Pituitary Dwarfism Ii

Laron-Type Isolated Somatotropin Defect

Primary Growth Hormone Resistance

Laron-Type Dwarfism

Laron Type Pituitary Dwarfism I

Primary Growth Hormone Insensitivity

Primary Gh Resistance

Gh-R Deficiency

Growth Hormone Receptor Defect

Laron-Type Pituitary Dwarfism

Laron-Type Short Stature

Severe Gh Insensitivity

Ghis

Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway

Complete Growth Hormone Insensitivity

Gh Receptor Deficiency

Primary Gh Insensitivity

Short Stature Due To Growth Hormone Resistance

LARS
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas
Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia

Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia

T-Cell Childhood Acute Lymphocytic Leukemia

Childhood T Lymphoblastic Leukemia/Lymphoma
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency

SCIDX1

XSCID

Scidx

X-Linked Scid

X-Scid

Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative

Scid, X-Linked

Immunodeficiency 4

Imd4

Gamma Chain Deficiency

Scid-X1

X-Linked Combined Immunodeficiency Diseases

Thymic Epithelial Hypoplasia

Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency

Severe Combined Immunodeficiency T- B+, X-Linked

Il2rg Scid, T- B+ Nk-

T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency

T-B+ Scid Due To Gamma Chain Deficiency

T-B+ Severe Combined Immunodeficiency, X-Linked

Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative

Agammaglobulinemia Swiss Type

Scid X-Linked

Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative

Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
Psoriasis
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06710 IL18R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus IL18R1 VGNC VGNC:30127
Macaca mulatta IL18R1 VGNC VGNC:73714
Rattus norvegicus IL18R1 RGD RGD:1308589
Felis catus IL18R1 VGNC VGNC:67764
Canis familiaris IL18R1 VGNC VGNC:41953
Mus musculus IL18R1 MGD MGI:105383
Others IL18R1 NCBI
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