1. Gene
  2. DCAF5 - DDB1 and CUL4 associated factor 5 Gene

DCAF5 - DDB1 and CUL4 associated factor 5 Gene

中文名称:DDB1 和 CUL4 相关因素 5

种属: Homo sapiens

同用名: BCRG2; BCRP2; WDR22; D14S1461E

基因 ID: 8816 | 基因类型: protein coding

关于 DCAF5

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,050,881-69,153,197 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 20.5), thyroid (RPKM 9.2) and 25 other tissues.

功能概要

预测参与蛋白质泛素化。 Cul4-RING E3 泛素连接酶复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCAF5 基因产物(4)

mRNA Protein Name
NM_001284206.1 NP_001271135.1 DDB1- and CUL4-associated factor 5 isoform 2
NM_001284207.1 NP_001271136.1 DDB1- and CUL4-associated factor 5 isoform 3
NM_001284208.2 NP_001271137.1 DDB1- and CUL4-associated factor 5 isoform 4
NM_003861.3 NP_003852.1 DDB1- and CUL4-associated factor 5 isoform 1

DCAF5 蛋白结构

WD40

WD40: WD domain, G-beta repeat (46 - 82)

WD40

WD40: WD domain, G-beta repeat (140 - 171)

WD40

WD40: WD domain, G-beta repeat (283 - 307)

WD40

WD40: WD domain, G-beta repeat (328 - 361)

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  • 942 a.a.
蛋白主名 其他名称

DDB1- and CUL4-associated factor 5

WD repeat-containing protein 22

DCAF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCAF5 Q96JK2 L3MBTL3 Homo sapiens Q96JM7
Anti Bait CoIP
29691401
Intra DCAF5 Q96JK2 DNMT1 Homo sapiens P26358
Anti Bait CoIP
29691401
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leiomyoma

Leiomyomatous Neoplasm

Leiomyomatous Tumor

Leiomyomas

Fibroid Tumor

Uterine Fibroids

Combined Oxidative Phosphorylation Deficiency 30

COXPD30

Combined Oxidative Phosphorylation Defect Type 30

Combined Oxidative Phosphorylation Deficiency, Type 30

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DCAF5 MGD MGI:2444785
Macaca mulatta DCAF5 VGNC VGNC:71683
Rattus norvegicus DCAF5 RGD RGD:1306535
Bos taurus DCAF5 VGNC VGNC:27905
Felis catus DCAF5 VGNC VGNC:61358
Canis familiaris DCAF5 VGNC VGNC:39794