2. Gene
  3. CCN5 - cellular communication network factor 5 Gene

CCN5 - cellular communication network factor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蜂窝通信网络因素 5

种属: Homo sapiens

同用名: CT58; WISP2; CTGF-L

基因 ID: 8839 | 基因类型: protein coding

关于 CCN5

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,714,861-44,727,811 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 5 paralogues. Biased expression in ovary (RPKM 59.2), fat (RPKM 22.7) and 9 other tissues.

功能概要

该基因编码 WNT1 诱导信号通路 (WISP) 蛋白亚家族的成员，属于结缔组织生长因子 (CTGF) 家族。 WNT1 是富含半胱氨酸的糖基化信号蛋白家族的成员，可介导多种发育过程。 CTGF 家族成员的特征在于四个保守的富含半胱氨酸的结构域：胰岛素样生长因子结合结构域、von Willebrand 因子 C 型模块、血小板反应蛋白结构域和 C 末端胱氨酸结样 (CT) 结构域。编码的蛋白质缺少与二聚化和肝素结合有关的 CT 结构域。它在氨基酸水平上与小鼠蛋白有 72% 的相同性。该基因可能位于与恶性转化相关的 WNT1 信号通路的下游。它在结肠肿瘤中的表达减少，而其他两个 WISP 成员在结肠肿瘤中过表达。它在骨组织中以高水平表达，并可能在调节骨转换中发挥重要作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the Other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

CCN5 基因产物(3)

mRNA Protein Name
NM_001323369.2 NP_001310298.1 CCN family member 5 isoform 2 precursor
NM_001323370.2 NP_001310299.1 CCN family member 5 isoform 1 precursor
NM_003881.4 NP_003872.1 CCN family member 5 isoform 1 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
10358067 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20531984 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCN5 蛋白结构

IGFBP

IGFBP: Insulin-like growth factor binding protein (26 - 78)

VWC

VWC: von Willebrand factor type C domain (100 - 163)

TSP_1

TSP_1: Thrombospondin type 1 domain (199 - 237)

  • 0
  • 100
  • 200
  • 250 a.a.
蛋白主名 其他名称

CCN family member 5

WNT1 inducible signaling pathway protein 2

CCN5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCN5 O76076 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
种属内
CCN5 O76076 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
种属内
CCN5 O76076 HOXA1 Homo sapiens P49639
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5
Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia

Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia

Corticotropin-Independent Macronodular Adrenal Hyperplasia

Cushing Syndrome Due To Macronodular Adrenal Hyperplasia

AIMAH1

Aimah

Massive Macronodular Adrenocortical Disease

Mmad

Primary Macronodular Adrenal Hyperplasia

Cushing Syndrome, Adrenal, Due To Aimah

Primary Bilateral Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenal Hyperplasia 1

Acth-Independent Cushing Syndrome

Adrenal Cushing Syndrome Due To Aimah

Acth-Independent Macronodular Adrenal Hyperplasia 2
Bladder Transitional Cell Papilloma

Bladder Papilloma

Transitional Cell Papilloma Of Bladder

Urinary Bladder Urothelial Papilloma

Urothelial Papilloma

Bladder Urothelial Papilloma
Primary Pigmented Nodular Adrenocortical Disease

Ppnad

Primary Pigmented Nodular Adrenal Dysplasia

Pigmented Nodular Adrenocortical Disease, Primary, 2

Pigmented Nodular Adrenocortical Disease, Primary, 1
Bladder Papillary Transitional Cell Neoplasm

Urinary Bladder Papillary Urothelial Neoplasm

Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm

Inverted Papilloma Of Urinary Tract

Papillary Transitional Cell Neoplasm Of The Urinary Tract

Urinary Tract Inverted Papilloma

Inverted Urothelial Papilloma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02114 CCN5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CCN5 RGD RGD:621867
Felis catus CCN5 VGNC VGNC:60548
Mus musculus CCN5 MGD MGI:1328326
Macaca mulatta CCN5 VGNC VGNC:84569
Canis familiaris CCN5 VGNC VGNC:48415
Bos taurus CCN5 VGNC VGNC:36945
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