VNN2 - vanin 2 Gene

中文名称：面包车 2

种属: Homo sapiens

同用名: FOAP-4; GPI-80

关于 VNN2

功能概要

该基因产物是 Vanin 蛋白质家族的成员，它们彼此之间以及与生物素酶具有广泛的序列相似性。该家族包括分泌蛋白和膜相关蛋白，据报道其中一些参与造血细胞运输。尚未证明任何 vanin 蛋白具有生物素酶活性，但是，它们具有泛酰乙胺酶活性，可能在氧化应激反应中发挥作用。编码的蛋白质是一种 GPI 锚定细胞表面分子，在中性粒细胞的跨内皮迁移中发挥作用。该基因与染色体 6q23-q24 上的其他两个 vanin 基因非常接近并处于相同的转录方向。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 5 月]

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each Other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two Other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]