2. Gene
  3. VNN1 - vanin 1 Gene

VNN1 - vanin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：面包车 1

种属: Homo sapiens

同用名: HDLCQ8; Tiff66

基因 ID: 8876 | 基因类型: protein coding

关于 VNN1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,680,849-132,714,055 (from NCBI)

This gene has 1 transcript (splice variant), 165 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 74.9), liver (RPKM 69.9) and 5 other tissues.

功能概要

该基因编码 vanin 蛋白家族的一个成员，它们彼此之间以及与生物素酶具有广泛的序列相似性。该家族包括分泌蛋白和膜相关蛋白，据报道其中一些参与造血细胞运输。尚未证明任何 vanin 蛋白具有生物素酶活性，但是，它们具有泛酰乙胺酶活性，可能在氧化应激反应中发挥作用。这种蛋白质与其小鼠同系物一样，可能是 GPI 锚定的细胞表面分子。小鼠蛋白由血管周围胸腺基质细胞表达，并调节 T 细胞祖细胞向胸腺的迁移。该基因与染色体 6q23-q24 上的另外两个 vanin 基因非常接近，并且处于相同的转录方向。[RefSeq 提供，2009 年 2 月]

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each Other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two Other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

VNN1 基因产物(1)

mRNA Protein Name
NM_004666.3 NP_004657.2 pantetheinase precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables pantetheine hydrolase activity IDA
IDA: 通过直接分析推断
11491533 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in pantothenate metabolic process IDA
IDA: 通过直接分析推断
11491533 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VNN1 蛋白结构

CN_hydrolase

CN_hydrolase: Carbon-nitrogen hydrolase (56 - 219)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
蛋白主名 其他名称

pantetheinase

pantetheine hydrolase

重组 VNN1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70502 Vanin-1 Protein, Human (HEK293, His) O95497 (Q22-S490) ≥95%

关联疾病

疾病名称 别名
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15666 VNN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus VNN1 MGD MGI:108395
Macaca mulatta VNN1 VGNC VGNC:83967
Bos taurus VNN1 VGNC VGNC:36807
Rattus norvegicus VNN1 RGD RGD:1310075
Others VNN1 NCBI
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