CDC16 - cell division cycle 16 Gene

中文名称：细胞分裂周期 16

种属: Homo sapiens

同用名: APC6; CUT9; ANAPC6; CDC16Hs

基因 ID: 8881 | 基因类型: protein coding

关于 CDC16

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:114,234,897-114,272,723 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质起蛋白质泛素连接酶的作用，是多蛋白 APC 复合物的组成部分。 APC 复合物是一种细胞周期蛋白降解系统，它通过靶向细胞周期蛋白以供 26S 蛋白酶体降解来控制有丝分裂的退出。 APC 复合体的每个组分蛋白在真核生物中都高度保守。该蛋白和其他 APC 复合蛋白包含一个四肽重复 (TPR) 结构域；通常参与蛋白质-蛋白质相互作用和多蛋白质复合物组装的蛋白质结构域。已经鉴定出编码不同蛋白质的多个选择性剪接的转录物变体。[RefSeq 提供，2016 年 1 月]

The protein encoded by this gene functions as a protein ubiquitin Ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S Proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and Other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

CDC16 基因产物(7)

mRNA	Protein	Name
NM_001078645.3	NP_001072113.1	cell division cycle protein 16 homolog isoform 1
NM_001318517.3	NP_001305446.1	cell division cycle protein 16 homolog isoform 2
NM_001318518.3	NP_001305447.1	cell division cycle protein 16 homolog isoform 3
NM_001330101.2	NP_001317030.1	cell division cycle protein 16 homolog isoform 2
NM_001330104.2	NP_001317033.1	cell division cycle protein 16 homolog isoform 4
NM_001330105.2	NP_001317034.1	cell division cycle protein 16 homolog isoform 4
NM_003903.5	NP_003894.3	cell division cycle protein 16 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19668213	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: 通过直接分析推断	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: 通过直接分析推断	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: 通过直接分析推断	29033132	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of anaphase-promoting complex	IDA IDA: 通过直接分析推断	16364912	GOA
part of anaphase-promoting complex	IPI IPI: 通过物理相互作用推断	27120157	GOA
located in centrosome	IDA IDA: 通过直接分析推断	7736578	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	7736578	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC16 蛋白结构

ANAPC3

TPR_8

TPR_11

0
100
200
300
400
500
620 a.a.

蛋白主名

其他名称

cell division cycle protein 16 homolog

anaphase-promoting complex, subunit 6

CDC16 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	26496610
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H Array	31515488
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H Prey Pooling	25416956
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Validated Y2H	32296183
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	TAP	20360068
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	33961781
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	35271311
种属内	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H	21988832
种属内	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
种属内	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
种属内	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Autosomal Dominant 65

DFNA65	Autosomal Dominant Nonsyndromic Deafness 65
Autosomal Dominant Deafness 65	Deafness, Autosomal Dominant, 65
Deafness, Autosomal Dominant, Type 65

Deafness, Autosomal Recessive 86

DFNB86	Autosomal Recessive Nonsyndromic Deafness 86
Autosomal Recessive Deafness 86	Deafness, Autosomal Recessive, 86
Deafness, Nonsyndromic, Autosomal Recessive, Type 86

Developmental And Epileptic Encephalopathy 16

DEE16	Epileptic Encephalopathy, Early Infantile, 16
Eiee16	Developmental And Epileptic Encephalopathy, 16
Early Infantile Epileptic Encephalopathy 16	Progressive Myoclonic Epilepsy With Dystonia
Pmed	Progressive Myoclonus Epilepsy With Dystonia
Encephalopathy, Epileptic, Early Infantile, Type 16

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome	Doors Syndrome
Digitorenocerebral Syndrome	Autosomal Recessive Deafness-Onychodystrophy Syndrome
Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome	DOORS
Drc Syndrome	Eronen Syndrome
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Brachydactyly Due To Absence Of Distal Phalanges
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome	Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome
Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome
Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome
Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome	Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome
Deafness, Congenital Onychodystrophy, Recessive Form	Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Epilepsy, Rolandic, With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp

Rolandic Epilepsy-Paroxysmal Exercise-Induced Dystonia-Writer'S Cramp Syndrome	EPRPDC
Re-Ped-Wc	Epilepsy, Rolandic, With Proxysmal Exercise-Induce Dystonia And Writer'S Cramp
Epilepsy, Rolandic, With Paroxysmal Exercise-Induce Dystonia And Writer'S Cramp	Rolandic Epilepsy With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp
Rolandic-Type Focal Motor Epilepsy And Exercise-Induced Dystonia	Rolandic Epilepsy Exercise-Induced Dystonia
Epilepsy, Rolandic With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp

Martsolf Syndrome 1

Martsolf Syndrome	Cataract-Intellectual Disability-Hypogonadism Syndrome
MARTS1	Marts
Cataract-Mental Retardation-Hypogonadism	Martsolf

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02287	CDC16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CDC16	VGNC	VGNC:70792
Rattus norvegicus	CDC16	RGD	RGD:1305076
Canis familiaris	CDC16	VGNC	VGNC:54931
Bos taurus	CDC16	VGNC	VGNC:50037
Mus musculus	CDC16	MGD	MGI:1917207
Felis catus	CDC16	VGNC	VGNC:60648

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