ENDOU - endonuclease, poly(U) specific Gene

中文名称：核酸内切酶，聚 (U) 特异性

种属: Homo sapiens

同用名: P11; PP11; PRSS26

关于 ENDOU

功能概要

该基因编码一种具有内切核糖核酸酶活性的蛋白质，可结合富含聚尿苷的单链 RNA。该基因最初是根据其在胎盘中的高表达来表征的，但被错误地表征为丝氨酸蛋白酶。在小鼠中，该基因通过调节 B 细胞活化诱导的细胞死亡 (AICD) 来促进对自身抗原的耐受性。该蛋白质可用作肿瘤标志物。已为该基因发现编码不同蛋白质同种型的多个可变剪接转录物变体。[RefSeq 提供，2020 年 7 月]

This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]