SKAP2 - src kinase associated phosphoprotein 2 Gene

中文名称：src 激酶相关磷蛋白 2

种属: Homo sapiens

同用名: PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM

关于 SKAP2

功能概要

该基因编码的蛋白质与 Src 激酶相关磷蛋白 1 具有同源性，是 Src 家族激酶的底物。它是一种衔接蛋白，被认为在 Src 信号通路和调节免疫系统的适当激活中起着重要作用。该蛋白质包含一个用于自二聚化的氨基末端卷曲螺旋结构域、一个与膜上脂质相互作用所需的 plecskstrin 同源 (PH) 结构域，以及一个位于羧基末端的 Src 同源 (SH3) 结构域。一些报道表明，该蛋白通过与肌动蛋白组装因子的相互作用抑制肌动蛋白聚合，并可能通过调节肌动蛋白组装来负向调节肿瘤的侵袭性。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 1 月]

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]