2. Gene
  3. SIGLEC10 - sialic acid binding Ig like lectin 10 Gene

SIGLEC10 - sialic acid binding Ig like lectin 10 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：唾液酸结合 Ig 样凝集素 10

种属: Homo sapiens

同用名: SLG2; PRO940; SIGLEC-10

基因 ID: 89790 | 基因类型: protein coding

关于 SIGLEC10

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,410,020-51,417,642 (from NCBI)

This gene has 11 transcripts (splice variants), 124 orthologues and 16 paralogues. Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues.

功能概要

Siglec 是在细胞表面表达的免疫球蛋白超家族的成员。大多数 Siglec 具有 1 个或多个基于细胞质免疫受体酪氨酸的抑制基序或 ITIM。 Siglec 通常在先天免疫系统的细胞上表达，但 B 细胞表达的 SIGLEC6 (MIM 604405) 除外。[OMIM 提供，2002 年 7 月]

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

SIGLEC10 基因产物(7)

mRNA Protein Name
NM_001171156.2 NP_001164627.1 sialic acid-binding Ig-like lectin 10 isoform 2 precursor
NM_001171157.2 NP_001164628.1 sialic acid-binding Ig-like lectin 10 isoform 3 precursor
NM_001171158.2 NP_001164629.1 sialic acid-binding Ig-like lectin 10 isoform 4 precursor
NM_001171159.2 NP_001164630.1 sialic acid-binding Ig-like lectin 10 isoform 5 precursor
NM_001171161.2 NP_001164632.1 sialic acid-binding Ig-like lectin 10 isoform 7 precursor
NM_001322105.2 NP_001309034.1 sialic acid-binding Ig-like lectin 10 isoform 8 precursor
NM_033130.5 NP_149121.2 sialic acid-binding Ig-like lectin 10 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IMP
IMP: 通过突变表型推断
12163025 GOA
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
12163025 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19264983 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response to wounding IPI
IPI: 通过物理相互作用推断
19264983 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
11284738 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIGLEC10 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (26 - 129)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (147 - 223)

I-set

I-set: Immunoglobulin I-set domain (264 - 340)

Ig_2

Ig_2: Immunoglobulin domain (369 - 442)

  • 0
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  • 697 a.a.
蛋白主名 其他名称

sialic acid-binding Ig-like lectin 10

sialic acid binding Ig-like lectin 10 Ig-like lectin 7

重组 SIGLEC10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72411 Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q96LC7-1 (M17-T546) ≥95%
HY-P72476 Siglec-10 Protein, Human (HEK293, Fc) Q96LC7-1 (M17-T546) ≥95%
HY-P76642 Siglec-10 Protein, Human (HEK293, His) AAI01726.1 (M17-N550) ≥95%
HY-P78205 Siglec-10 Protein, Human (Biotinylated, HEK293, His-Avi) Q96LC7-1 (M17-T546) ≥95%
HY-P78206 Siglec-10 Protein, Human (Biotinylated, R119A, HEK293, His-Avi) Q96LC7-1 (M17-T546, R119A) ≥95%
HY-P78514 Siglec-10 Protein, Human (R119A, HEK293, His-Avi) Q96LC7-1 (M17-T546, R119A) ≥95%
HY-P78516 Siglec-10 Protein, Human (HEK293, Fc-Avi) Q96LC7-1 (M17-T546) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10091 CD24/Siglec-10 blocking peptide, CSBP Inhibitor 99.59% 否
HY-RS12898 SIGLEC10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SIGLEC10 VGNC VGNC:77237
Rattus norvegicus SIGLEC10 RGD RGD:1307441
Mus musculus SIGLEC10 MGD MGI:2443630
Macaca fascicularis SIGLEC10 NCBI NCBI:102125591
Others SIGLEC10 NCBI
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