2. Gene
  3. NAV3 - neuron navigator 3 Gene

NAV3 - neuron navigator 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经元导航器 3

种属: Homo sapiens

同用名: POMFIL1; unc53H3; STEERIN3

基因 ID: 89795 | 基因类型: protein coding

关于 NAV3

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:77,571,862-78,213,010 (from NCBI)

This gene has 16 transcripts (splice variants), 215 orthologues and 2 paralogues. Broad expression in brain (RPKM 3.5), ovary (RPKM 2.8) and 14 other tissues.

功能概要

该基因属于神经元导航家族，主要在神经系统中表达。编码的蛋白质包含与多种细胞活动相关的 ATP 酶的卷曲螺旋结构域和保守的 AAA 结构域特征。该基因类似于 unc-53，一种参与轴突导向的秀丽隐杆线虫基因。已经描述了该基因的多个可变剪接转录物变体，但只有一个已确定其全长性质。[RefSeq 提供，2008 年 7 月]

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

NAV3 基因产物(2)

mRNA Protein Name
NM_001024383.2 NP_001019554.1 neuron navigator 3 isoform 1
NM_014903.6 NP_055718.4 neuron navigator 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
25678558 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
25678558 GOA
involved in negative regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
16166283 GOA
involved in negative regulation of microtubule depolymerization IMP
IMP: 通过突变表型推断
25678558 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: 通过突变表型推断
25678558 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with microtubule end IMP
IMP: 通过突变表型推断
25678558 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAV3 蛋白结构

CH

CH: Calponin homology (CH) domain (83 - 182)

AAA_14

AAA_14: AAA domain (2051 - 2162)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2385 a.a.
蛋白主名 其他名称

neuron navigator 3

pore membrane and/or filament interacting like protein 1

关联疾病

疾病名称 别名
Panniculitis

Nodular Panniculitis
Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency

CSID

Si Deficiency

Congenital Sucrose Intolerance

Disaccharide Intolerance

Sucrase-Isomaltase Deficiency

Disaccharide Intolerance I

Congenital Sucrose-Isomaltose Malabsorption

Sucrose-Isomaltose Malabsorption, Congenital

Sucrose Intolerance, Congenital

Congenital Sucrase-Isomaltose Malabsorption

Congenital Sucrose-Isomaltase Malabsorption

Disaccharide Intolerance, 1

Sucrose Intolerance Congenital

Sucrose-Isomaltase Malabsorption, Congenital

Disaccharidase Deficiency

Invertase Deficiency

Sucrase-Alpha-Dextrinase Deficiency

Disaccharide Intolerance Type I

Csid - [Congenital Sucrase-Isomaltase Deficiency]

Sucrose Intolerance Of Newborn

Sucrose Intolerance

Sucrase Deficiency

Disaccharide Malabsorption

Intestinal Disaccharidase Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09048 NAV3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NAV3 VGNC VGNC:43631
Mus musculus NAV3 MGD MGI:2183703
Macaca mulatta NAV3 VGNC VGNC:74969
Rattus norvegicus NAV3 RGD RGD:1306259
Felis catus NAV3 VGNC VGNC:63728
Bos taurus NAV3 VGNC VGNC:31892
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