2. Gene
  3. RPS6KA4 - ribosomal protein S6 kinase A4 Gene

RPS6KA4 - ribosomal protein S6 kinase A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶 A4

种属: Homo sapiens

同用名: MSK2; RSK-B; S6K-alpha-4

基因 ID: 8986 | 基因类型: protein coding

关于 RPS6KA4

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,359,162-64,372,215 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 7 paralogues. Ubiquitous expression in spleen (RPKM 12.2), colon (RPKM 9.2) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶 RSK (核糖体 S6 激酶) 家族的成员。该激酶包含 2 个不同的激酶催化结构域并磷酸化各种底物，包括 CREB1 和 ATF1。编码的蛋白质还可以磷酸化组蛋白 H3 以调节某些炎症基因。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

RPS6KA4 基因产物(4)

mRNA Protein Name
NM_001006944.2 NP_001006945.1 ribosomal protein S6 kinase alpha-4 isoform b
NM_001300802.2 NP_001287731.1 ribosomal protein S6 kinase alpha-4 isoform c
NM_001318361.2 NP_001305290.1 ribosomal protein S6 kinase alpha-4 isoform d
NM_003942.3 NP_003933.1 ribosomal protein S6 kinase alpha-4 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9792677 GOA
enables histone H3S10 kinase activity IMP
IMP: 通过突变表型推断
12773393 GOA
enables histone H3S28 kinase activity IMP
IMP: 通过突变表型推断
12773393 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9792677 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9792677 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-1-mediated signaling pathway IMP
IMP: 通过突变表型推断
20018936 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9792677 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20018936 GOA
involved in post-translational protein modification IMP
IMP: 通过突变表型推断
12773393 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9792677 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9792677 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9792677 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6KA4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (33 - 301)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (321 - 365)

Pkinase

Pkinase: Protein kinase domain (416 - 673)

  • 0
  • 200
  • 400
  • 600
  • 772 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase alpha-4

90 kDa ribosomal protein S6 kinase 4

RPS6KA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS6KA4 O75676 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Coffin-Lowry Syndrome

CLS

Coffin Syndrome 1

Coffin Syndrome

Intellectual Disability With Osteocartilaginous Abnormalities

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Lowry Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148065 FMF-06-098-1 / 否
HY-RS12257 RPS6KA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RPS6KA4 RGD RGD:1307277
Felis catus RPS6KA4 VGNC VGNC:64757
Canis familiaris RPS6KA4 VGNC VGNC:45741
Macaca mulatta RPS6KA4 VGNC VGNC:76930
Mus musculus RPS6KA4 MGD MGI:1930076
Bos taurus RPS6KA4 VGNC VGNC:34143
Others RPS6KA4 NCBI
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