LIMD1 - LIM domain containing 1 Gene

中文名称：含 LIM 域 1

种属: Homo sapiens

基因 ID: 8994 | 基因类型: protein coding

关于 LIMD1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,594,751-45,686,341 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 16.2), thyroid (RPKM 9.3) and 25 other tissues.

功能概要

预测启用转录辅阻遏物活性。参与多个过程，包括河马信号的负调控；基因表达的调节；和对缺氧的反应。通过 miRNA 在 P 体组装和基因沉默的上游或内部起作用。位于多个细胞成分中，包括 P 体；粘附连接；和粘着斑。 RISC 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Acts upstream of or within P-body assembly and gene silencing by miRNA. Located in several cellular components, including P-body; adherens junction; and focal adhesion. Part of RISC complex. [provided by Alliance of Genome Resources, Apr 2022]

LIMD1 基因产物(1)

mRNA	Protein	Name
NM_014240.3	NP_055055.1	LIM domain-containing protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15542589	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within P-body assembly	IMP IMP: 通过突变表型推断	20616046	GOA
involved in cell migration	IMP IMP: 通过突变表型推断	21834987	GOA
involved in cytoskeleton organization	IMP IMP: 通过突变表型推断	21834987	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IMP IMP: 通过突变表型推断	20616046	GOA
acts upstream of or within miRNA-mediated post-transcriptional gene silencing	IMP IMP: 通过突变表型推断	20616046	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15542589	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	22286099	GOA
involved in negative regulation of hippo signaling	IDA IDA: 通过直接分析推断	20303269	GOA
involved in phosphorylation	IDA IDA: 通过直接分析推断	18439753	GOA
involved in regulation of cell shape	IMP IMP: 通过突变表型推断	21834987	GOA
involved in response to hypoxia	IDA IDA: 通过直接分析推断	22286099	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	20616046	GOA
part of RISC complex	IDA IDA: 通过直接分析推断	20616046	GOA
located in adherens junction	IDA IDA: 通过直接分析推断	20303269	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15542589	GOA
located in focal adhesion	IDA IDA: 通过直接分析推断	18439753	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15542589	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LIMD1 蛋白结构

LIM

0
200
400
600
676 a.a.

蛋白主名

其他名称

LIM domain-containing protein 1

LIM domains containing 1

LIMD1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LIMD1	Q9UGP4	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	28683311

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07659	LIMD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	LIMD1	VGNC	VGNC:30888
Macaca mulatta	LIMD1	VGNC	VGNC:74268
Mus musculus	LIMD1	MGD	MGI:1352502
Rattus norvegicus	LIMD1	RGD	RGD:1309830
Canis familiaris	LIMD1	VGNC	VGNC:42679
Felis catus	LIMD1	VGNC	VGNC:68052

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LIMD1 - LIM domain containing 1 Gene

关于 LIMD1

功能概要

LIMD1 基因产物(1)

LIMD1 蛋白结构

LIMD1 蛋白互作信息

关联疾病

直系同源

热门区域

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LIMD1 - LIM domain containing 1 Gene

关于 LIMD1

功能概要

LIMD1 基因产物(1)

LIMD1 蛋白结构

LIMD1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z