LACRT - lacritin Gene

中文名称：催泪素

种属: Homo sapiens

基因 ID: 90070 | 基因类型: protein coding

关于 LACRT

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,630,811-54,634,895 (from NCBI)

This gene has 4 transcripts (splice variants), 18 orthologues and 1 paralogue. Restricted expression toward salivary gland (RPKM 2.0).

功能概要

该基因编码的蛋白质在泪腺中高度表达，主要定位于分泌颗粒和分泌液。它增加泪腺腺泡细胞分泌，促进导管细胞增殖，并通过酪氨酸磷酸化和钙释放刺激信号传导。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

LACRT 基因产物(1)

mRNA	Protein	Name
NM_033277.2	NP_150593.1	extracellular glycoprotein lacritin precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables collagen binding	IDA IDA: 通过直接分析推断	11419941	GOA
enables growth factor activity	IDA IDA: 通过直接分析推断	16982797	GOA
enables laminin-1 binding	IDA IDA: 通过直接分析推断	11419941	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11419941	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcineurin-NFAT signaling cascade	IDA IDA: 通过直接分析推断	16923831	GOA
involved in calcium-mediated signaling	IDA IDA: 通过直接分析推断	11419941	GOA
involved in defense response to bacterium	IDA IDA: 通过直接分析推断	24942736	GOA
involved in epithelial structure maintenance	IDA IDA: 通过直接分析推断	25034600	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	26670139	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: 通过直接分析推断	26670139	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IDA IDA: 通过直接分析推断	16923831	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: 通过直接分析推断	25530855	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11419941	GOA
involved in positive regulation of epithelial cell proliferation	IDA IDA: 通过直接分析推断	16923831	GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing	IDA IDA: 通过直接分析推断	25530855	GOA
involved in positive regulation of macroautophagy	IDA IDA: 通过直接分析推断	23640897	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	11419941	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: 通过直接分析推断	16923831	GOA
involved in positive regulation of secretion	IDA IDA: 通过直接分析推断	11419941	GOA
involved in protein localization to Golgi apparatus	IDA IDA: 通过直接分析推断	16923831	GOA
involved in tear secretion	IDA IDA: 通过直接分析推断	25034600	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular region	IDA IDA: 通过直接分析推断	17850790	GOA
located in secretory granule	IDA IDA: 通过直接分析推断	11419941	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

extracellular glycoprotein lacritin

重组 LACRT 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70911	Lacritin Protein, Human (His)	Q9GZZ8 (A19-A138)	≥95%

关联疾病

疾病名称

别名

Blepharitis

Chronic Follicular Conjunctivitis

Apperceptive Agnosia

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Eyelid Disease

Eyelid Diseases

Eyelid Disorders

Cicatricial Entropion

Keratopathy

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

Conjunctivochalasis

Filamentary Keratitis

Orbital Cellulitis

Cellulitis Of Orbit

Acute Orbital Inflammation

Acute Inflammation Of Orbit

Papillary Conjunctivitis

Accommodative Spasm

Spasm Of Accommodation	Cyclospasm
Ciliary Muscle Spasm	Ciliary Body Spasm

Giant Papillary Conjunctivitis

Gpc	Conjunctivitis Giant Papillary
Conjunctivitis, Giant Papillary	Chronic Giant Papillary Conjunctivitis
Chronic Papillary Conjunctivitis

Exposure Keratitis

Exposure Keratoconjunctivitis

Lagophthalmic Keratitis

Entropion

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis	Thygeson Superficial Punctate Keratitis
Thygeson'S Superficial Punctate Keratitis	Thygeson Superficial Punctate Keratopathy
Punctate Epithelial Keratitis

Excessive Tearing

Epiphora	Lacrimal Apparatus Diseases
Excessive Tear Production	Watering Eye

Corneal Disease

Corneal Diseases

Corneal Disorders

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LACRT - lacritin Gene

关于 LACRT

功能概要

LACRT 基因产物(1)

重组 LACRT 蛋白

关联疾病

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