2. Gene
  3. PHLDB2 - pleckstrin homology like domain family B member 2 Gene

PHLDB2 - pleckstrin homology like domain family B member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：pleckstrin 同源性样域家族 B 成员 2

种属: Homo sapiens

同用名: LL5b; LL5beta

基因 ID: 90102 | 基因类型: protein coding

关于 PHLDB2

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:111,732,496-111,976,517 (from NCBI)

This gene has 18 transcripts (splice variants), 319 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 18.1), kidney (RPKM 15.7) and 24 other tissues.

功能概要

启用钙粘蛋白结合活动。涉及多个过程，包括粘着斑组装的负调控；细胞骨架组织的调节；和胚胎发育的调节。位于多个细胞成分中，包括基底皮层；细胞前沿；和中间丝细胞骨架。与粘着斑共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of Cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cell leading edge; and intermediate filament Cytoskeleton. Colocalizes with focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

PHLDB2 基因产物(4)

mRNA Protein Name
NM_001134437.2 NP_001127909.1 pleckstrin homology-like domain family B member 2 isoform b
NM_001134438.2 NP_001127910.1 pleckstrin homology-like domain family B member 2 isoform a
NM_001134439.2 NP_001127911.1 pleckstrin homology-like domain family B member 2 isoform a
NM_145753.2 NP_665696.1 pleckstrin homology-like domain family B member 2 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20236936 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of protein localization IMP
IMP: 通过突变表型推断
24859005 GOA
involved in microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
24859005 GOA
involved in negative regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
24859005 GOA
involved in negative regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
24859005 GOA
involved in negative regulation of wound healing, spreading of epidermal cells IMP
IMP: 通过突变表型推断
24859005 GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IGI
IGI: 通过遗传相互作用推断
23940118 GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
IMP: 通过突变表型推断
23940118 GOA
involved in regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
23940118 GOA
involved in regulation of gastrulation IMP
IMP: 通过突变表型推断
23940118 GOA
involved in regulation of microtubule cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
23940118 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal cortex IDA
IDA: 通过直接分析推断
23940118 GOA
located in cell cortex IDA
IDA: 通过直接分析推断
24120883 GOA
located in cell leading edge IDA
IDA: 通过直接分析推断
24859005 GOA
colocalizes with focal adhesion IDA
IDA: 通过直接分析推断
24859005 GOA
located in podosome IDA
IDA: 通过直接分析推断
23525008 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHLDB2 蛋白结构

PH

PH: PH domain (1146 - 1241)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1253 a.a.
蛋白主名 其他名称

pleckstrin homology-like domain family B member 2

LL5 beta

PHLDB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PHLDB2 Q86SQ0 FLNA Homo sapiens P21333
Anti Tag CoIP
20236936
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10446 PHLDB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PHLDB2 VGNC VGNC:49874
Bos taurus PHLDB2 VGNC VGNC:32838
Rattus norvegicus PHLDB2 RGD RGD:1591402
Mus musculus PHLDB2 MGD MGI:2444981
Macaca mulatta PHLDB2 VGNC VGNC:75883
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