2. Gene
  3. CCRL2 - C-C motif chemokine receptor like 2 Gene

CCRL2 - C-C motif chemokine receptor like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CC 基序趋化因子受体样 2

种属: Homo sapiens

同用名: HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B

基因 ID: 9034 | 基因类型: protein coding

关于 CCRL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,407,259-46,409,523 (from NCBI)

This gene has 7 transcripts (splice variants), 144 orthologues and 23 paralogues. Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues.

功能概要

该基因编码趋化因子受体样蛋白，预计为七次跨膜蛋白，与 CCR1 关系最密切。趋化因子及其受体介导的信号转导对于将效应免疫细胞募集到炎症部位至关重要。该基因在原代嗜中性粒细胞和原代单核细胞中以高水平表达，并在嗜中性粒细胞活化和单核细胞向巨噬细胞分化过程中进一步上调。该基因的功能未知。该基因被映射到趋化因子受体基因簇所在的区域。[RefSeq 提供，2008 年 7 月]

This gene encodes a Chemokine Receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the Chemokine Receptor gene cluster is located. [provided by RefSeq, Jul 2008]

CCRL2 基因产物(2)

mRNA Protein Name
NM_001130910.2 NP_001124382.1 C-C chemokine receptor-like 2 isoform 2
NM_003965.5 NP_003956.2 C-C chemokine receptor-like 2 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CCR chemokine receptor binding IPI
IPI: 通过物理相互作用推断
20002784 GOA
enables chemokine receptor binding IPI
IPI: 通过物理相互作用推断
14530373 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
20002784 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCRL2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (56 - 300)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

C-C chemokine receptor-like 2

atypical chemokine receptor 5

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Inflammatory Bowel Disease 18

IBD18
Autoimmune Disease Of Skin And Connective Tissue
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02175 CCRL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CCRL2 VGNC VGNC:38918
Rattus norvegicus CCRL2 RGD RGD:1311811
Macaca mulatta CCRL2 VGNC VGNC:70743
Bos taurus CCRL2 VGNC VGNC:26990
Mus musculus CCRL2 MGD MGI:1920904
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