2. Gene
  3. GPRC5A - G protein-coupled receptor class C group 5 member A Gene

GPRC5A - G protein-coupled receptor class C group 5 member A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 C 类组 5 成员 A

种属: Homo sapiens

同用名: RAI3; TIG1; RAIG1; GPCR5A; PEIG-1

基因 ID: 9052 | 基因类型: protein coding

关于 GPRC5A

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,891,562-12,917,937 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues and 3 paralogues. Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues.

功能概要

该基因编码 3 G 蛋白偶联受体家族的成员，其特征是标志性的 7 跨膜结构域基序。所编码的蛋白质可能参与维甲酸和 G 蛋白信号通路之间的相互作用。视黄酸在发育、细胞生长和分化中起着关键作用。该基因可能在胚胎发育和上皮细胞分化中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

GPRC5A 基因产物(1)

mRNA Protein Name
NM_003979.4 NP_003970.1 retinoic acid-induced protein 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25311788 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
18000218 GOA
located in vesicle IDA
IDA: 通过直接分析推断
25468996 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPRC5A 蛋白结构

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (38 - 268)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

retinoic acid-induced protein 3

G-protein coupled receptor family C group 5 member A

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-117295A 7-Fluorotryptamine hydrochloride 98.86% 否
HY-RS05749 GPRC5A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPRC5A VGNC VGNC:73159
Rattus norvegicus GPRC5A RGD RGD:1310804
Canis familiaris GPRC5A VGNC VGNC:41450
Bos taurus GPRC5A VGNC VGNC:29606
Mus musculus GPRC5A MGD MGI:1891250
Felis catus GPRC5A VGNC VGNC:69226
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