2. Gene
  3. PAPSS1 - 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Gene

PAPSS1 - 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：3'-磷酸腺苷 5'-磷酸硫酸合酶 1

种属: Homo sapiens

同用名: SK1; PAPSS; ATPSK1

基因 ID: 9061 | 基因类型: protein coding

关于 PAPSS1

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:107,613,666-107,720,234 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues.

功能概要

三引发磷酸腺苷 5 引发磷酸盐 (PAPS) 是所有磺基转移酶 (SULT) 酶的硫酸盐供体共底物 (Xu et al., 2000 [PubMed 10679223]) 。 SULT 催化许多内源性和外源性化合物 (包括药物和其他外源性物质) 的硫酸盐结合。在人类中，PAPS 是由腺苷 5-主要三磷酸 (ATP) 和无机硫酸盐通过 2 种亚型 PAPSS1 和 PAPSS2 (MIM 603005) 合成的。[OMIM 提供，2008 年 3 月]

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) Enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and Other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

PAPSS1 基因产物(1)

mRNA Protein Name
NM_005443.5 NP_005434.4 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenylylsulfate kinase activity IDA
IDA: 通过直接分析推断
14747722 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
33961781 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
14747722 GOA
enables sulfate adenylyltransferase (ATP) activity IDA
IDA: 通过直接分析推断
14747722 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
IDA: 通过直接分析推断
14747722 GOA
involved in sulfate assimilation IDA
IDA: 通过直接分析推断
14747722 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PAPSS1 蛋白结构

APS_kinase

APS_kinase: Adenylylsulphate kinase (51 - 207)

PUA_2

PUA_2: PUA-like domain (232 - 385)

ATP-sulfurylase

ATP-sulfurylase: ATP-sulfurylase (394 - 618)

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  • 500
  • 624 a.a.
蛋白主名 其他名称

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1

PAPSS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PAPSS1 O43252 PAPSS2 Homo sapiens O95340
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Achondrogenesis, Type Ib

ACG1B

Achondrogenesis Type Ib

Achondrogenesis Type 1b

Achondrogenesis Ib

Achondrogenesis Fraccaro Type

Achondrogenesis, Fraccaro Type

Achondrogenesis, Parenti-Fraccaro Type

Achondrogenesis 1b

Acg-Ib

Fraccaro Achondrogenesis
Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations

Spondyloepiphyseal Dysplasia

Chst3-Related Skeletal Dysplasia

Humerospinal Dysostosis

Spondyloepiphyseal Dysplasia, Omani Type

Chondrodysplasia With Multiple Dislocations

SEDCJD

Hsd

Cdmd

Humero-Spinal Dysostosis

Kozlowski Celermajer Tink Syndrome

Chondrodysplasia With Congenital Joint Dislocations, Chst3 Type

Larsen Syndrome, Recessive Type

Humero-Spinal Dysostosis With Congenital Heart Disease

Omani Type

Sed

Chst3 Deficiency

Chst3-Related Dysplasia

Recessive Larsen Syndrome

Autosomal Recessive Larsen Syndrome

Sed With Luxations, Chst3 Type

Sed, Omani Type

Sdcd, Chst3 Type

Spondyloepiphyseal Dysplasia With Congenital Joint Dyslocations, Chst3 Type

Sed Omani Type

Spondyloepiphyseal Dysplasia Omani Type

Larsen Syndrome, Autosomal Recessive

Mucopolysaccharidosis Iv

Spondyloepiphyseal Dysplasia, Congenita
Cortisone Reductase Deficiency

11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of

Cortrd

Hsd 11b1 Deficiency
Brachyolmia

Brachyrachia
Atelosteogenesis

Atelosteogenesis, Type 1
Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal
Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus

Giant Congenital Melanocytic Nevus

Gmn

Congenital Pigmented Nevus

Lcmn

Gphn

Giant Congenital Nevus

Bathing Trunk Nevus

Congenital Giant Pigmented Nevus

Congenital Hairy Nevus

Giant Hairy Nevus

Giant Pigmented Nevus

Congenital Giant Pigmented Nevus Of Skin

Congenital Melanocytic Nevus Syndrome

Giant Congenital Melanocytic Nevi

Giant Congenital Pigmented Nevus

Melanocytic Nevus Syndrome, Congenital
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10030 PAPSS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PAPSS1 RGD RGD:1308081
Felis catus PAPSS1 VGNC VGNC:68693
Bos taurus PAPSS1 VGNC VGNC:53770
Macaca mulatta PAPSS1 VGNC VGNC:75757
Canis familiaris PAPSS1 VGNC VGNC:44258
Mus musculus PAPSS1 MGD MGI:1330587
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