CLDN6 - claudin 6 Gene

中文名称：紧密连接蛋白 6

种属: Homo sapiens

基因 ID: 9074 | 基因类型: protein coding

关于 CLDN6

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,014,712-3,018,183 (from NCBI)

This gene has 3 transcripts (splice variants), 76 orthologues and 22 paralogues. Low expression observed in reference dataset.

功能概要

紧密连接代表上皮或内皮细胞片中细胞间粘附的一种模式，在细胞周围形成连续密封，并作为物理屏障防止溶质和水自由通过细胞旁空间。这些连接由面向外的细胞质小叶中的多组连续网络链组成，在面向内的胞质外小叶中具有互补的凹槽。该基因编码紧密连接链的一个组成部分，它是密蛋白家族的一员。该蛋白是一种完整的膜蛋白，是丙型肝炎病毒的进入辅因子之一。该基因甲基化可能参与食管肿瘤的发生。该基因与 16 号染色体上的另一个家族成员 CLDN9 相邻。[RefSeq 提供，2010 年 8 月]

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

CLDN6 基因产物(1)

mRNA	Protein	Name
NM_021195.5	NP_067018.2	claudin-6 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20375010	GOA
enables virus receptor activity	IMP IMP: 通过突变表型推断	20375010	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	20375010	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLDN6 蛋白结构

PMP22_Claudin

0
100
200
220 a.a.

蛋白主名

其他名称

claudin-6

skullin

CLDN6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLDN6	P56747	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
种属内	CLDN6	P56747	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
种属内	CLDN6	P56747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
种属内	CLDN6	P56747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
种属内	CLDN6	P56747	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
种属内	CLDN6	P56747	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
种属内	CLDN6	P56747	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
种属内	CLDN6	P56747	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
种属内	CLDN6	P56747	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
种属内	CLDN6	P56747	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
种属内	CLDN6	P56747	MAPK8	Homo sapiens	P45983	Anti Bait CoIP	36935496

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CLDN6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77899	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, solution)	P56747 (M1-V220)	≥95%
HY-P77900	Claudin-6/CLDN6 Protein-VLP, Human (Biotinylated, HEK293)	P56747 (M1-V220)	≥95%
HY-P700406	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, His)	P56747 (M1-V220)	/

关联疾病

疾病名称

别名

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Lymphoplasmacyte-Rich Meningioma

Lymphoplasmocyte-Rich Meningioma

Meningioma

Large Cell Medulloblastoma

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99413	IMAB027	Inhibitor	98.98%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02774	CLDN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990369	Anti-CLDN6 Antibody (AB3-7)	Inhibitor	97.56%	否
HY-P990368	Anti-CLDN6 Antibody (AB1-11)	Inhibitor	/	否
HY-P990371	Anti-CLDN6 Antibody (IM-301)	Inhibitor	/	否
HY-P990579	DS-9606A	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CLDN6	VGNC	VGNC:80560
Macaca mulatta	CLDN6	VGNC	VGNC:71251
Rattus norvegicus	CLDN6	RGD	RGD:1308837
Bos taurus	CLDN6	VGNC	VGNC:27418
Canis familiaris	CLDN6	VGNC	VGNC:39322
Mus musculus	CLDN6	MGD	MGI:1859284
Macaca fascicularis	CLDN6	NCBI	NCBI:102140361
Others	CLDN6	NCBI

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