PRMT9 - protein arginine methyltransferase 9 Gene

中文名称：蛋白质精氨酸甲基转移酶 9

种属: Homo sapiens

同用名: PRMT10

关于 PRMT9

功能概要

该基因编码 II 型甲基转移酶。 PRMTs 对目标蛋白的翻译后修饰在许多生物过程中起着重要的调节作用，PRMTs 通过将甲基从 S-腺苷-L-甲硫氨酸转移到精氨酸的胍基氮原子来甲基化精氨酸残基。由该基因编码的蛋白质甲基化剪接体相关蛋白 145 以调节可变剪接并充当小核核糖核蛋白成熟的调节剂。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2017 年 4 月]

This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]