2. Gene
  3. ZNF598 - zinc finger protein 598, E3 ubiquitin ligase Gene

ZNF598 - zinc finger protein 598, E3 ubiquitin ligase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指蛋白 598，E3 泛素连接酶

种属: Homo sapiens

同用名: HEL2

基因 ID: 90850 | 基因类型: protein coding

关于 ZNF598

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,997,654-2,009,821 (from NCBI)

This gene has 9 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 7.9), spleen (RPKM 7.8) and 25 other tissues.

功能概要

锌指蛋白结合核酸并在各种细胞功能中发挥重要作用，包括细胞增殖、分化和凋亡。这种蛋白质和 Grb10 相互作用的 GYF 蛋白 2 已被确定为哺乳动物 4EHP (m4EHP) 复合体的组成部分。该复合物被认为在胚胎发育中起着翻译阻遏物的作用。[RefSeq 提供，2012 年 10 月]

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and Apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

ZNF598 基因产物(3)

mRNA Protein Name
NM_001405664.1 NP_001392593.1 E3 ubiquitin-protein ligase ZNF598 isoform 2
NM_001405665.1 NP_001392594.1 E3 ubiquitin-protein ligase ZNF598 isoform 3
NM_178167.5 NP_835461.2 E3 ubiquitin-protein ligase ZNF598 isoform 1
蛋白主名 其他名称

E3 ubiquitin-protein ligase ZNF598

ZNF598 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF598 Q86UK7 YWHAE Homo sapiens P62258
Crosslink
36931259
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16157 ZNF598 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZNF598 RGD RGD:1304900
Canis familiaris ZNF598 VGNC VGNC:48771
Macaca mulatta ZNF598 VGNC VGNC:99638
Mus musculus ZNF598 MGD MGI:2670965
Felis catus ZNF598 VGNC VGNC:67332
Bos taurus ZNF598 VGNC VGNC:37309
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