2. Gene
  3. FMNL3 - formin like 3 Gene

FMNL3 - formin like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：形式样 3

种属: Homo sapiens

同用名: FRL2; WBP3; FHOD3; WBP-3

基因 ID: 91010 | 基因类型: protein coding

关于 FMNL3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,636,499-49,707,405 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 8.1), testis (RPKM 7.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质包含一个甲酸同源 2 结构域，与小鼠 Wbp3 蛋白质具有高度序列同一性。已经描述了编码不同亚型的两种替代转录本。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

FMNL3 基因产物(3)

mRNA Protein Name
NM_001367835.1 NP_001354764.1 formin-like protein 3 isoform 3
NM_175736.5 NP_783863.4 formin-like protein 3 isoform 1
NM_198900.3 NP_944489.2 formin-like protein 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
24223803 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
21834987 GOA
involved in cytoskeleton organization IMP
IMP: 通过突变表型推断
21834987 GOA
involved in filopodium assembly IDA
IDA: 通过直接分析推断
24223803 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
21834987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21834987 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FMNL3 蛋白结构

Drf_GBD

Drf_GBD: Diaphanous GTPase-binding Domain (28 - 144)

Drf_GBD

Drf_GBD: Diaphanous GTPase-binding Domain (221 - 278)

Drf_FH3

Drf_FH3: Diaphanous FH3 Domain (281 - 478)

FH2

FH2: Formin Homology 2 Domain (562 - 926)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1027 a.a.
蛋白主名 其他名称

formin-like protein 3

WW domain binding protein 3

关联疾病

疾病名称 别名
Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma
Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish

Fdd

Familial Danish Dementia

Heredopathia Ophthalmootoencephalica

Hooe

Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis

Adan Amyloidosis

Itm2b-Related Cerebral Amyloid Angiopathy 2

Itm2b Amyloidosis

Familial Cerebral Amyloid Angiopathy

Itm2b-Related Amyloidosis

Itm2b-Related Cerebral Amyloid Angiopathy

Familial Dementia, Danish Type

Cerebral Amyloid Angiopathy, Itm2b-Related 2

CAA-ITM2B2

Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis

Dementia, Familial, Danish
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05004 FMNL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FMNL3 RGD RGD:1583854
Canis familiaris FMNL3 VGNC VGNC:40915
Bos taurus FMNL3 VGNC VGNC:29048
Mus musculus FMNL3 MGD MGI:109569
Macaca mulatta FMNL3 VGNC VGNC:72560
Felis catus FMNL3 VGNC VGNC:62306
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