ATG12 - autophagy related 12 Gene

中文名称：自噬相关 12

种属: Homo sapiens

同用名: APG12; FBR93; APG12L; HAPG12

基因 ID: 9140 | 基因类型: protein coding

关于 ATG12

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,828,200-115,841,565 (from NCBI)

This gene has 13 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in brain (RPKM 8.9), fat (RPKM 8.2) and 25 other tissues.

功能概要

自噬是大量蛋白质降解的过程，其中包括细胞器在内的细胞质成分被包裹在称为自噬体的双膜结构中，并被输送到溶酶体或液泡中进行降解。 ATG12 是一种参与自噬的酵母蛋白的人类同系物 (Mizushima 等人，1998 [PubMed 9852036]) 。[OMIM 提供，2008 年 3 月]

Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in Autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]

ATG12 基因产物(2)

mRNA	Protein	Name
NM_001277783.2	NP_001264712.1	ubiquitin-like protein ATG12 isoform 2
NM_004707.4	NP_004698.3	ubiquitin-like protein ATG12 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9852036	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in macroautophagy	IMP IMP: 通过突变表型推断	25484072	GOA
involved in negative regulation of defense response to virus	IDA IDA: 通过直接分析推断	19666601	GOA
involved in positive regulation of viral translation	IDA IDA: 通过直接分析推断	19666601	GOA
involved in regulation of autophagosome maturation	IMP IMP: 通过突变表型推断	22342342	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Atg12-Atg5-Atg16 complex	IPI IPI: 通过物理相互作用推断	23202584	GOA
located in autophagosome	IDA IDA: 通过直接分析推断	24954904	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATG12 蛋白结构

APG12

0
100
140 a.a.

蛋白主名

其他名称

ubiquitin-like protein ATG12

APG12 autophagy 12-like

ATG12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ATG12	O94817	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	ATG12	O94817	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	ATG12	O94817	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	ATG12	O94817	IER2	Homo sapiens	Q9BTL4	Y2H Array	32296183
种属内	ATG12	O94817	IER2	Homo sapiens	Q9BTL4	Y2H Prey Pooling	32296183
种属内	ATG12	O94817	IER2	Homo sapiens	Q9BTL4	Validated Y2H	32296183
种属内	ATG12	O94817	SERTAD2	Homo sapiens	Q14140	Y2H Array	32296183
种属内	ATG12	O94817	SERTAD2	Homo sapiens	Q14140	Y2H Prey Pooling	32296183
种属内	ATG12	O94817	SERTAD2	Homo sapiens	Q14140	Validated Y2H	32296183
种属内	ATG12	O94817	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
种属内	ATG12	O94817	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
种属内	ATG12	O94817	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Y2H Prey Pooling	32296183
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	35271311
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Validated Y2H	32296183
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	ITC	23202584
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	20562859
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Y2H Array	32296183
种属内	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Anti Bait CoIP	17353931

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Stomatitis

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Mouth Disease

Mouth Diseases

Mouth Disorders

Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14	ARMD14
Macular Degeneration, Age-Related, 14, Reduced Risk Of	Macular Degeneration, Age-Related, Type 14

Acute Laryngopharyngitis

Pharyngolaryngitis	Laryngopharyngitis
Hypopharyngitis

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-156966	ATG12-ATG3 inhibitor 1	Inhibitor	99.31%	否
HY-162932	ATG12-IN-1	Inhibitor	/	否
HY-RS01140	ATG12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ATG12	VGNC	VGNC:67741
Mus musculus	ATG12	MGD	MGI:1914776
Canis familiaris	ATG12	VGNC	VGNC:38216
Macaca mulatta	ATG12	VGNC	VGNC:110488
Rattus norvegicus	ATG12	RGD	RGD:1306306
Bos taurus	ATG12	VGNC	VGNC:26250

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ATG12 - autophagy related 12 Gene

关于 ATG12

功能概要

ATG12 基因产物(2)

ATG12 蛋白结构

ATG12 蛋白互作信息

关联疾病

直系同源

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ATG12 - autophagy related 12 Gene

关于 ATG12

功能概要

ATG12 基因产物(2)

ATG12 蛋白结构

ATG12 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z