1. Gene
  2. PDCD5 - programmed cell death 5 Gene

PDCD5 - programmed cell death 5 Gene

中文名称:程序性细胞死亡 5

种属: Homo sapiens

同用名: TFAR19

基因 ID: 9141 | 基因类型: protein coding

关于 PDCD5

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:32,581,190-32,587,453 (from NCBI)

This gene has 8 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in testis (RPKM 17.5), adrenal (RPKM 13.5) and 25 other tissues.

功能概要

该基因编码一种在细胞凋亡过程中上调的蛋白质,在细胞凋亡过程中它会迅速从细胞质转移到细胞核。编码的蛋白质可能是 K (赖氨酸) 乙酰转移酶 5 (一种参与转录、DNA 损伤反应和细胞周期控制的蛋白质) 的重要调节因子,可抑制其蛋白酶体依赖性降解。已在 5 号和 12 号染色体上鉴定出假基因[RefSeq 提供,2010 年 12 月]

This gene encodes a protein that is upregulated during Apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

PDCD5 基因产物(1)

mRNA Protein Name
NM_004708.4 NP_004699.1 programmed cell death protein 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetyltransferase activator activity IDA
IDA: 通过直接分析推断
24012345 GOA
enables beta-tubulin binding IPI
IPI: 通过物理相互作用推断
24375412 GOA
enables heparin binding IDA
IDA: 通过直接分析推断
17165023 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24012345 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
24012345 GOA
involved in negative regulation of chaperone-mediated protein folding IMP
IMP: 通过突变表型推断
24375412 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
9920759 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
24012345 GOA
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
16374546 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
24012345 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PDCD5 蛋白结构

dsDNA_bind

dsDNA_bind: Double-stranded DNA-binding domain (9 - 113)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

programmed cell death protein 5

TF-1 cell apoptosis-related protein 19

PDCD5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDCD5 O14737 TRIM35 Homo sapiens Q9UPQ4-2 32296183
种属内
PDCD5 O14737 TRIM35 Homo sapiens Q9UPQ4-2 32296183
种属内
PDCD5 O14737 TRIM35 Homo sapiens Q9UPQ4-2 32296183
种属内
PDCD5 O14737 RAD18 Homo sapiens Q9NS91 32296183
种属内
PDCD5 O14737 RAD18 Homo sapiens Q9NS91 32296183
种属内
PDCD5 O14737 RAD18 Homo sapiens Q9NS91 32296183
种属内
PDCD5 O14737 PICK1 Homo sapiens Q9NRD5 32296183
种属内
PDCD5 O14737 PICK1 Homo sapiens Q9NRD5 32296183
种属内
PDCD5 O14737 PICK1 Homo sapiens Q9NRD5 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDCD5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71019 PDCD5 Protein, Human (His) O14737 (M1-Y125) ≥95%

关联疾病

疾病名称 别名
Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma

Fhcc

Fibrolamellar Hepatocarcinoma

Hepatocellular Carcinoma, Fibrolamellar

Oncocytic Hepatocellular Tumor

Eosinophilic Glassy Cell Hepatoma

Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis

Fl-Hcc

Fibrolamellar Oncocytic Hepatoma

Hepatocellular Carcinoma With Increased Stromal Fibrosis

Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PDCD5 MGD MGI:1913538
Rattus norvegicus PDCD5 RGD RGD:1310561
Bos taurus PDCD5 VGNC VGNC:32662
Felis catus PDCD5 VGNC VGNC:68745
Canis familiaris PDCD5 VGNC VGNC:44339
Others PDCD5 NCBI