2. Gene
  3. NEURL1 - neuralized E3 ubiquitin protein ligase 1 Gene

NEURL1 - neuralized E3 ubiquitin protein ligase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经化 E3 泛素蛋白连接酶 1

种属: Homo sapiens

同用名: neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1

基因 ID: 9148 | 基因类型: protein coding

关于 NEURL1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,493,705-103,592,546 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.6), colon (RPKM 2.4) and 15 other tissues.

功能概要

预测可实现翻译因子活性、非核酸结合和泛素蛋白连接酶活性。参与 Notch 信号通路的负调控；细胞群增殖的负调节；和细胞凋亡过程的正调控。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein Ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NEURL1 基因产物(1)

mRNA Protein Name
NM_004210.5 NP_004201.3 E3 ubiquitin-protein ligase NEURL1

NEURL1 蛋白结构

Neuralized

Neuralized: Neuralized (62 - 130)

Neuralized

Neuralized: Neuralized (294 - 362)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (519 - 567)

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  • 574 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase NEURL1

RING finger protein 67

NEURL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NEURL1 O76050 YWHAE Homo sapiens P62258
Crosslink
36931259
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Malignant Astrocytoma

Astrocytic Tumor

Astrocytoma Of Brain

Astrocytoma Of Cerebrum

Astroglioma

Cerebral Astrocytoma

Astrocytoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Syndromic X-Linked Intellectual Disability Siderius Type

Mrxssd

Siderius-Hamel Syndrome

Siderius X-Linked Mental Retardation Syndrome
Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome

SCDO1

Vertebral Anomalies

Spondylothoracic Dysplasia

Costovertebral Dysplasia

Spondylothoracic Dysostosis

Spondylocostal Dysostosis 1

Autosomal Recessive Spondylocostal Dysostosis 1

Spondylocostal Dysostosis, Autosomal Recessive, 1

Doid:0112365

Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09219 NEURL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09220 NEURL1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NEURL1 MGD MGI:1334263
Macaca mulatta NEURL1 VGNC VGNC:75319
Rattus norvegicus NEURL1 RGD RGD:1307021
Canis familiaris NEURL1 VGNC VGNC:43750
Felis catus NEURL1 VGNC VGNC:68463
Bos taurus NEURL1 VGNC VGNC:32013
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