2. Gene
  3. FIBP - FGF1 intracellular binding protein Gene

FIBP - FGF1 intracellular binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：FGF1 细胞内结合蛋白

种属: Homo sapiens

同用名: FGFIBP; FIBP-1; TROFAS

基因 ID: 9158 | 基因类型: protein coding

关于 FIBP

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,883,740-65,888,471 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 27.1), brain (RPKM 21.5) and 25 other tissues.

功能概要

酸性成纤维细胞生长因子对多种不同细胞类型具有促有丝分裂作用，并通过刺激有丝分裂发生或诱导形态学变化和分化发挥作用。 FIBP 蛋白是一种细胞内蛋白，可选择性地结合酸性成纤维细胞生长因子 (aFGF) 。据推测，FIBP 可能参与 aFGF 的促有丝分裂作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Acidic Fibroblast Growth Factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic Fibroblast Growth Factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FIBP 基因产物(2)

mRNA Protein Name
NM_004214.5 NP_004205.2 acidic fibroblast growth factor intracellular-binding protein isoform b
NM_198897.2 NP_942600.1 acidic fibroblast growth factor intracellular-binding protein isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
9806903 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
9806903 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9806903 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FIBP 蛋白结构

FIBP

FIBP: Acidic fibroblast growth factor binding (FIBP) (3 - 364)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

acidic fibroblast growth factor intracellular-binding protein

aFGF intracellular-binding protein

重组 FIBP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72641 FIBP Protein, Human O43427-2/NP_004205.2 (M1-D357) ≥95%

关联疾病

疾病名称 别名
Thauvin-Robinet-Faivre Syndrome

Tall Stature-Intellectual Disability-Renal Anomalies Syndrome

TROFAS
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder
Overgrowth Syndrome

Overgrowth

Congenital Malformation Syndromes Involving Early Overgrowth
Coloboma, Ocular, Autosomal Dominant

Coloboma, Ocular

Coloboma Of Iris, Choroid, And Retina

Coi

Coloboma, Uveoretinal

COAD

Ocular Coloboma

Uveoretinal Coloboma

Chronic Obstructive Airway Disease
Coloboma Of Macula

Coloboma

Congenital Ocular Coloboma

Microphthalmia, Isolated, With Coloboma

Agenesis Of Macula

Hereditary Macular Coloboma

Ocular Coloboma

Coloboma Of Eye

Macular Coloboma

Uveoretinal Coloboma
Protoplasmic Astrocytoma

Protoplasmic Astrocytic Tumor

Astrocytoma Protoplasmic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04942 FIBP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FIBP VGNC VGNC:29006
Felis catus FIBP VGNC VGNC:62271
Canis familiaris FIBP VGNC VGNC:40878
Mus musculus FIBP MGD MGI:1926233
Macaca mulatta FIBP VGNC VGNC:72663
Rattus norvegicus FIBP RGD RGD:628715
Others FIBP NCBI
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