1. Gene
  2. PCSK7 - proprotein convertase subtilisin/kexin type 7 Gene

PCSK7 - proprotein convertase subtilisin/kexin type 7 Gene

中文名称:前蛋白转化酶枯草杆菌蛋白酶/kexin 7 型

种属: Homo sapiens

同用名: LPC; PC7; PC8; SPC7

基因 ID: 9159 | 基因类型: protein coding

关于 PCSK7

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,204,337-117,232,073 (from NCBI)

This gene has 15 transcripts (splice variants), 204 orthologues and 9 paralogues. Ubiquitous expression in endometrium (RPKM 37.0), urinary bladder (RPKM 33.8) and 25 other tissues.

功能概要

该基因编码枯草杆菌蛋白酶样原蛋白转化酶家族的一个成员,其中包括通过分泌途径的受调节或组成性分支处理蛋白质和肽前体运输的蛋白酶。它编码一种在许多组织中表达的 1 型膜结合蛋白酶,包括神经内分泌、肝脏、肠道和大脑。编码的蛋白质在 ER 中经历初始自催化处理事件,然后通过核内体分类到反式高尔基体网络,在那里发生第二次自催化事件并获得催化活性。该基因编码七个碱性氨基酸特异性成员之一,这些成员在单个或成对的碱性残基处切割其底物。它可以处理原白蛋白,并被认为负责激活 HIV 包膜糖蛋白 gp160 和 gp140。该基因与管家基因的转录调控有关,并在铁代谢的调控中发挥作用。与 B 细胞淋巴瘤相关的 t (11;14) (q23;q32) 染色体易位发生在该基因与其反向对应基因之间。[RefSeq 提供,2014 年 2 月]

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]

PCSK7 基因产物(1)

mRNA Protein Name
NM_004716.4 NP_004707.2 proprotein convertase subtilisin/kexin type 7 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
15606899 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within protein processing IDA
IDA: 通过直接分析推断
15606899 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
9341152 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PCSK7 蛋白结构

Peptidase_S8

Peptidase_S8: Subtilase family (182 - 474)

P_proprotein

P_proprotein: Proprotein convertase P-domain (525 - 612)

  • 0
  • 200
  • 400
  • 600
  • 785 a.a.
蛋白主名 其他名称

proprotein convertase subtilisin/kexin type 7

lymphoma proprotein convertase

PCSK7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PCSK7 Q16549 JPH3 Homo sapiens Q8WXH2 32814053
种属内
PCSK7 Q16549 JPH3 Homo sapiens Q8WXH2 32814053
种属内
PCSK7 Q16549 JPH3 Homo sapiens Q8WXH2 32814053
种属内
PCSK7 Q16549 NOS3 Homo sapiens P29474 32814053
种属内
PCSK7 Q16549 NOS3 Homo sapiens P29474 32814053
种属内
PCSK7 Q16549 NOS3 Homo sapiens P29474 32814053
种属内
PCSK7 Q16549 KLK6 Homo sapiens Q92876 32814053
种属内
PCSK7 Q16549 KLK6 Homo sapiens Q92876 32814053
种属内
PCSK7 Q16549 KLK6 Homo sapiens Q92876 32814053
种属内
PCSK7 Q16549 TGFBR2 Homo sapiens P37173 32814053
种属内
PCSK7 Q16549 TGFBR2 Homo sapiens P37173 32814053
种属内
PCSK7 Q16549 TGFBR2 Homo sapiens P37173 32814053
种属内
PCSK7 Q16549 SERPINH1 Homo sapiens P50454 32814053
种属内
PCSK7 Q16549 SERPINH1 Homo sapiens P50454 32814053
种属内
PCSK7 Q16549 SERPINH1 Homo sapiens P50454 32814053
种属内
PCSK7 Q16549 PRKACA Homo sapiens P17612 32814053
种属内
PCSK7 Q16549 PRKACA Homo sapiens P17612 32814053
种属内
PCSK7 Q16549 PRKACA Homo sapiens P17612 32814053
种属内
PCSK7 Q16549 NDUFV2 Homo sapiens P19404 32814053
种属内
PCSK7 Q16549 NDUFV2 Homo sapiens P19404 32814053
种属内
PCSK7 Q16549 NDUFV2 Homo sapiens P19404 32814053
种属内
PCSK7 Q16549 PECAM1 Homo sapiens P16284 32814053
种属内
PCSK7 Q16549 PECAM1 Homo sapiens P16284 32814053
种属内
PCSK7 Q16549 PECAM1 Homo sapiens P16284 32814053
种属内
PCSK7 Q16549 GFAP Homo sapiens P14136 32814053
种属内
PCSK7 Q16549 GFAP Homo sapiens P14136 32814053
种属内
PCSK7 Q16549 GFAP Homo sapiens P14136 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Apricot Allergy

Prunus Armeniaca Fruit Allergy

Somatization Disorder

Somatoform Disorders

Briquet'S Disorder

Polysomatising Disorder

Somatisation Disorder

Somatoform Disorder

Heel Spur

Calcaneal Spur

Nerve Compression Syndrome

Entrapment Neuropathies

Compression Neuropathy

Entrapment Neuropathy

Peripheral Nerve Entrapment Syndrome

Nerve Compression Syndromes

Hereditary Liability To Pressure Palsies

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PCSK7 VGNC VGNC:44325
Mus musculus PCSK7 MGD MGI:107421
Macaca mulatta PCSK7 VGNC VGNC:75788
Bos taurus PCSK7 VGNC VGNC:32649
Rattus norvegicus PCSK7 RGD RGD:3275
Felis catus PCSK7 VGNC VGNC:68734