PCSK7 - proprotein convertase subtilisin/kexin type 7 Gene

中文名称：前蛋白转化酶枯草杆菌蛋白酶/kexin 7 型

种属: Homo sapiens

同用名: LPC; PC7; PC8; SPC7

关于 PCSK7

功能概要

该基因编码枯草杆菌蛋白酶样原蛋白转化酶家族的一个成员，其中包括通过分泌途径的受调节或组成性分支处理蛋白质和肽前体运输的蛋白酶。它编码一种在许多组织中表达的 1 型膜结合蛋白酶，包括神经内分泌、肝脏、肠道和大脑。编码的蛋白质在 ER 中经历初始自催化处理事件，然后通过核内体分类到反式高尔基体网络，在那里发生第二次自催化事件并获得催化活性。该基因编码七个碱性氨基酸特异性成员之一，这些成员在单个或成对的碱性残基处切割其底物。它可以处理原白蛋白，并被认为负责激活 HIV 包膜糖蛋白 gp160 和 gp140。该基因与管家基因的转录调控有关，并在铁代谢的调控中发挥作用。与 B 细胞淋巴瘤相关的 t (11;14) (q23;q32) 染色体易位发生在该基因与其反向对应基因之间。[RefSeq 提供，2014 年 2 月]

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]