CD3G - CD3 gamma subunit of T-cell receptor complex Gene

中文名称：T 细胞受体复合物的 CD3 γ 亚基

种属: Homo sapiens

同用名: T3G; IMD17; CD3GAMMA; CD3-GAMMA

基因 ID: 917 | 基因类型: protein coding

关于 CD3G

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,344,344-118,355,161 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues.

功能概要

该基因编码的蛋白质是 CD3-γ 多肽，它与 CD3-epsilon、-delta 和 -zeta 以及 T 细胞受体 alpha/beta 和 gamma/delta 异二聚体一起形成 T 细胞受体-CD3 复合物.该复合物在将抗原识别与多种细胞内信号转导途径偶联方面起着重要作用。编码 epsilon、γ 和 delta 多肽的基因位于 11 号染色体上的同一簇中。该基因的缺陷与 T 细胞免疫缺陷有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

CD3G 基因产物(1)

mRNA	Protein	Name
NM_000073.3	NP_000064.1	T-cell surface glycoprotein CD3 gamma chain precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IDA IDA: 通过直接分析推断	14967045	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables transmembrane signaling receptor activity	IMP IMP: 通过突变表型推断	12794121	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell surface receptor signaling pathway	IMP IMP: 通过突变表型推断	12407027	GOA
involved in establishment or maintenance of cell polarity	IMP IMP: 通过突变表型推断	12407027	GOA
involved in protein transport	IMP IMP: 通过突变表型推断	12794121	GOA
involved in regulation of lymphocyte apoptotic process	IMP IMP: 通过突变表型推断	12407027	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of alpha-beta T cell receptor complex	IDA IDA: 通过直接分析推断	9485181	GOA
part of alpha-beta T cell receptor complex	IPI IPI: 通过物理相互作用推断	31461748	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	31461748	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD3G 蛋白结构

ITAM

0
100
182 a.a.

蛋白主名

其他名称

T-cell surface glycoprotein CD3 gamma chain

CD3g antigen, gamma polypeptide (TiT3 complex)

CD3G 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD3G	P09693	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
种属内	CD3G	P09693	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
种属内	CD3G	P09693	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
种属内	CD3G	P09693	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
种属内	CD3G	P09693	MAL	Homo sapiens	P21145	Validated Y2H	32296183
种属内	CD3G	P09693	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
种属内	CD3G	P09693	TMEM19	Homo sapiens	Q96HH6	Y2H Prey Pooling	32296183
种属内	CD3G	P09693	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
种属内	CD3G	P09693	TMEM19	Homo sapiens	Q96HH6	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD3G 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77609	CD3E-CD3G Heterodimer Protein, Human (HEK293, His)	P07766 (D23-E120)&P09693 (Q23-Q106)	≥95%
HY-P77611	CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc)	P07766 (D23-D126)&P09693 (Q23-S116)	≥95%
HY-P77613	CD3E-CD3G Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P07766 (D23-D126)&P09693 (Q23-S116)	≥95%
HY-P78753	CD3 gamma Protein, Human (HEK293, Fc)	P09693 (Q23-S116)	≥95%

CD3G 抗体

目录号	产品名	应用	反应物种
HY-P80601	CD3G Antibody	WB, IHC-P, IP	Human

关联疾病

疾病名称

别名

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Immunodeficiency 18

IMD18	Cd3-Epsilon Deficiency
Immunodeficiency 18, Scid Variant	Cd3epsilon Deficiency
Immunodeficiency 18, Severe Combined Immunodeficiency Variant	Immunodeficiency, Type 18

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Cd3zeta Deficiency

Lymphopenia

Lymphocytopenia

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02244	CD3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990698	Umizortamig		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CD3G	MGD	MGI:88333
Canis familiaris	CD3G	VGNC	VGNC:38957
Rattus norvegicus	CD3G	RGD	RGD:1307718
Felis catus	CD3G	VGNC	VGNC:60617
Bos taurus	CD3G	VGNC	VGNC:27031
Macaca mulatta	CD3G	VGNC	VGNC:100904
Macaca fascicularis	CD3G	NCBI	NCBI:102134381
Others	CD3G	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CD3G - CD3 gamma subunit of T-cell receptor complex Gene

关于 CD3G

功能概要

CD3G 基因产物(1)

CD3G 蛋白结构

CD3G 蛋白互作信息

重组 CD3G 蛋白

CD3G 抗体

关联疾病

直系同源

热门区域

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CD3G - CD3 gamma subunit of T-cell receptor complex Gene

关于 CD3G

功能概要

CD3G 基因产物(1)

CD3G 蛋白结构

CD3G 蛋白互作信息

重组 CD3G 蛋白

CD3G 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z